Cognitive impairment in early stages of multiple sclerosis
Cognitive impairment in early stages of multiple sclerosis
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DOI：
10.1007/s10072-010-0376-4
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发表时间：
2010-11-01
影响因子：
3.3
通讯作者：
Razzolini, L.
中科院分区：
文献类型：
--
作者：
Amato, Maria Pia;Portaccio, E.;Razzolini, L.
认知功能障碍涉及 40-65% 的多发性硬化症患者，并且会对功能产生很大影响。自疾病早期阶段起，它就可以在所有疾病表型中检测到，并且往往会随着时间的推移而进展。最常见的是记忆力、复杂注意力、信息处理速度和执行功能。认知变化和磁共振成像（MRI）结果之间的关系可能涉及不同区域的变化，包括白质病变、皮质和深部灰质以及传统MRI上表现正常的脑组织。寻找有效的治疗策略是一项重大任务，涉及药物和康复方法的使用。为了预防或延缓认知障碍的发展，早期使用可以控制大脑疾病负担的疾病缓解药物治疗似乎是非常可取的。
Cognitive dysfunction involves 40-65% of multiple sclerosis patients and can have a great functional impact. It can be detected in all the disease phenotypes since the early stages of the disease, and tends to progress over time. Memory, complex attention, information-processing speed and executive functions are most commonly involved. The relationship between cognitive changes and magnetic resonance imaging (MRI) findings may involve changes in different areas, including white matter lesions, cortical and deep grey matter and normal appearing brain tissue on conventional MRI. The search for effective therapeutic strategies is a major undertaking, involving the use of both pharmacologic and rehabilitative approaches. Early treatment with disease-modifying drugs that can contain the disease burden in the brain seems to be highly advisable in order to prevent or delay the development of cognitive impairment.