Mesencephalic dopamine neurons are essential for modafinil‐induced arousal
Mesencephalic dopamine neurons are essential for modafinil‐induced arousal
复制标题
DOI：
10.1111/bph.15660
复制
发表时间：
2021-08
影响因子：
7.3
通讯作者：
Yan-fei Yang;Hui Dong;Yan Shen;Lei Li;M. Lazarus;W. Qu;Zhi-Li Huang
中科院分区：
文献类型：
--
作者：
Yan-fei Yang;Hui Dong;Yan Shen;Lei Li;M. Lazarus;W. Qu;Zhi-Li Huang
莫达非尼是一种有效的促醒药物，用于治疗发作性睡病，滥用率低。虽然先前的研究表明莫达非尼诱导的觉醒依赖于多巴胺受体和转运体，但多巴胺传递系统的具体部分仍不清楚。在这里，我们研究了中脑多巴胺神经元在莫达非尼诱发觉醒中的作用。
Modafinil is a potent eugeroic (wakefulness‐promoting) drug that is prescribed to treat narcolepsy and has a low incidence of abuse. Although previous studies have shown that modafinil‐induced arousal depends on the dopamine receptors and transporters, the specific part/s of the dopamine transmitter system underlying this mechanism remained unclear. Here, we investigated the role of mesencephalic dopamine neurons in modafinil‐evoked arousal.