Urinary iodine excretion (UIE) estimated by iodine/creatinine ratio from spot urine in Chinese school-age children
Urinary iodine excretion (UIE) estimated by iodine/creatinine ratio from spot urine in Chinese school-age children
复制标题
根据中国学龄儿童现场尿液中的碘/肌酐比值估算尿碘排泄量（UIE）
DOI：
10.1111/cen.13282
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发表时间：
2017-04-01
影响因子：
3.2
通讯作者：
Zhang, Wanqi
中科院分区：
文献类型：
--
作者：
Chen, Wen;Li, Xiang;Zhang, Wanqi
目的评价尿碘/肌酐比值（UI/Cr）估算尿碘排泄量（UIE）的有效性，方法采用横断面调查方法，对24 h尿进行2次重复采集，并在1个月内采集尿标本，测定尿碘浓度（UIC）、尿肌酐浓度（UCr）、尿碘浓度（UIC）、尿碘浓度（UIC）、尿碘浓度（UIC）、尿肌酐浓度（UCr）、尿碘浓度（UIC）、尿碘浓度（UIC）、尿肌酐浓度（UCr）、尿碘浓度（UIC）、尿碘浓度（UIC）、尿碘浓度（UCr）、尿碘浓度（UIC）、尿碘浓度（UIC）、尿碘浓度（UIC）、尿肌酐浓度（UCr）、尿碘浓度（UIC）、尿碘浓度（UIC）、尿碘浓度（UCr）、尿碘浓度（UIC）、尿碘浓度（UIC）、尿肌酐浓度（UCr）、尿碘浓度（UIC）、尿碘浓度（UIC）、尿碘浓度（U测定尿点和24小时尿量（Uvol）。测量的24小时UIE由24小时UIC乘以24小时Uvol计算，而估计的24小时UIE由点UI/Cr乘以24小时尿肌酐排泄计算结果两次重复采集的24 h Uvol无显著性差异（P = 0.70），而斑点UIC、24 h UIC、两组间尿碘比值（UI/Cr）及24 h尿碘指数（UIE）差异有显著性（P <00 5）。第一次采集时估计的24小时UIE为247（136 - 431）g/天，低于测量的24小时UIE 329（183 - 536）g/天（P <0.001），而在第二次采样中没有观察到显著差异（P = 0.30），因为估计的24小时UIE为355（168 - 624）g/天，而测量的24小时UIE为355（168 - 624）g/天，h UIE 350（181 - 615）克/天。第一次采集时的UIC（r = 0.57，P <0.001）、UI/Cr（r = 0.63，P <0.001）和24 h UIE（r = 0.83，P <0.001）与24 h UIE测定值高度相关。同样，在第二次采样中，点UIC（r = 060，P <0001），点UI/Cr（r = 072，P <0001）和估计的24小时UIE（r = 089，P <0001）也与测量的24小时UIE相关。Bland-Altman结果表明，预计95%的受试者位于一致性限度（LOA）内，但显示估计的24小时UIE低估了尿碘排泄量。此外，24 h UIE的估计值与实测值的一致性为中等至良好，kappa值分别为055和066。结论尿碘/肌酐比值估计24 h UIE可作为儿童尿碘排泄量的一种有效、可靠的替代方法。
ObjectiveTo assess the validity of urinary iodine excretion (UIE) estimated by urinary iodine/creatinine ratio (UI/Cr) from spot urines in Chinese school-age children.DesignA cross-sectional survey was performed in which twice-repeated collections of 24-h urine, and spot urine samples were obtained within 1 month.MeasurementsUrinary iodine concentration (UIC), urinary creatinine concentration (UCr), urine volume (Uvol) of spot and 24-h urine samples were measured. Measured 24-h UIE was calculated from 24-h UIC multiplied by 24-h Uvol, while the estimated 24-h UIE was calculated from spot UI/Cr multiplied by 24-h urinary creatinine excretion (24-h UCrE).ResultsNo significant difference was observed in 24-h Uvol between two repeated collections (P = 070), while spot UIC, 24-h UIC, spot UI/Cr and measured 24-h UIE were significantly different (P < 005). The estimated 24-h UIE was 247 (136-431) g/day in the first collection, lower than the measured 24-h UIE of 329 (183-536) g/day (P < 0001), while no significant difference was observed (P = 030) in the second sampling as the estimated 24-h UIE was 355 (168-624) g/day and the measured 24-h UIE 350 (181-615) g/day. The spot UIC (r = 057, P < 0001), spot UI/Cr (r = 063, P < 0001) and the estimated 24-h UIE (r = 083, P < 0001) were strongly correlated with the measured 24-h UIE in the first collection. Likewise, in the second sampling, spot UIC (r = 060, P < 0001), spot UI/Cr (r = 072, P < 0001) and the estimated 24-h UIE (r = 089, P < 0001) were also correlated with measured 24-h UIE. The Bland-Altman results indicated 95% of subjects were expected to locate within the limits of agreement (LOA), but showed an underestimation of the urinary iodine excretion by the estimated 24-h UIE. In addition, moderate-to-good agreement was found for the estimated and measured 24-h UIE, with kappa values of 055 and 066.ConclusionsEstimated 24-h UIE by UI/Cr ratio from spot urine could represent a valid and reliable alternative for measured 24-h UIE in estimating iodine excretion in children.