Variability in rates of affective disorders in relatives of depressed and normal probands.
Variability in rates of affective disorders in relatives of depressed and normal probands.
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DOI：
10.1001/archpsyc.1982.04290120033006
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发表时间：
1982-12
影响因子：
--
通讯作者：
M. Weissman;K. Kidd;B. Prusoff
中科院分区：
文献类型：
--
作者：
M. Weissman;K. Kidd;B. Prusoff
对抑郁症先证者的家族研究中，亲属情感障碍的绝对发病率各不相同。在一项对215名轻度和重度非双相型重性抑郁症患者及正常先证者以及1331名成年一级亲属的研究中，人们试图解释差异的来源。结果显示出家族聚集性，尽管情感障碍绝对发病率的聚集程度在亲属中因用于亲属的抑郁症定义、数据来源以及亲属样本的构成而异。尽管存在这种变异性，正常人和抑郁症先证者的亲属之间发病率的差异程度保持恒定。抑郁症患者亲属的情感障碍发病率总是高于正常先证者的亲属。抑郁症患者亲属和正常先证者亲属之间抑郁症发病率的差异程度大约在两倍到五倍之间。
Familial studies of depressed probands vary in the absolute rates of affective disorders in relatives. In a study of 215 mild and severely depressed nonbipolar major depressives and normal probands and 1,331 adult first-degree relatives, attempts were made to account for the sources of variance. The results demonstrated familial aggregation, although degree of aggregation of absolute rates of affective disorders varied among relatives according to the definition of depression used for the relatives, the source of data, and the composition of the relative sample. Despite this variability, the magnitude of the difference in rates between relatives of the normal persons and of the depressed probands remained constant. The rates of affective disorders were always higher in the relatives of the depressed than in the relatives of the normal probands. The magnitude of the difference in rates of depression between the relatives of the depressed subjects and the relatives of the normal probands ranged approximately between twofold and fivefold.