Poly(ethylene glycol)-containing hydrogels in drug delivery
Poly(ethylene glycol)-containing hydrogels in drug delivery
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DOI：
10.1016/s0168-3659(99)00027-9
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发表时间：
1999-11-01
影响因子：
10.8
通讯作者：
Lowman, AM
中科院分区：
文献类型：
--
作者：
Peppas, NA;Keys, KB;Lowman, AM
使用水凝胶作为蛋白质递送的载体已经成为最近重要研究的主题。在我们最近的工作中，我们已经表明，从含有聚（乙二醇）（PEG）的水凝胶中扩散控制蛋白质的递送是可能的，并且由三维结构控制。此外，这些水凝胶载体中的许多是粘膜粘附的，并且可以用于蛋白质递送。PEG星星聚合物凝胶也已经通过γ-辐射制备，并且已经用于具有和不具有分子印迹的蛋白质递送。在小体积中大量官能团的存在使得这些聚合物对于在生物和药物应用中的使用是重要的。PEG星星聚合物水凝胶的合成使用γ-辐射和使用溶胀技术进行了表征。进行平衡溶胀研究以研究分子量、星星臂数、浓度和辐射剂量的影响。(C)1999 Elsevier Science B. V.保留所有权利。
The use of hydrogels as carriers for protein delivery has been a subject of significant recent research. In our recent work, we have shown that diffusion controlled delivery of proteins from hydrogels containing poly(ethylene glycol) (PEG) can be possible and controlled by the three-dimensional structure. In addition, a number of these hydrogel carriers are mucoadhesive and can be used for protein delivery. PEG star polymer gels have also been prepared by gamma-irradiation and have been used for protein delivery with and without molecular imprinting. The presence of a large number of functional groups in a small volume makes these polymers important for use in biological and pharmaceutical applications. PEG star polymer hydrogels were synthesized using gamma-irradiation and were characterized using swelling techniques. Equilibrium swelling studies were conducted to investigate the effects of molecular weight, number of star arms, concentration, and radiation dose. (C) 1999 Elsevier Science B.V. All rights reserved.