Assessment of diastolic function with Doppler tissue imaging to predict genotype in preclinical hypertrophic cardiomyopathy
Assessment of diastolic function with Doppler tissue imaging to predict genotype in preclinical hypertrophic cardiomyopathy
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DOI：
10.1161/01.cir.0000019070.70491.6d
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发表时间：
2002-06-25
期刊：
影响因子：
37.8
通讯作者：
Solomon, SD
中科院分区：
文献类型：
--
作者：
Ho, CY;Sweitzer, NK;Solomon, SD
背景-不明原因的左心室肥厚被认为是肥厚型心肌病的诊断，但不能确定所有受遗传影响的个体。改变舒张功能已被假设为代表HCM的早期表现之前，LVH的发展，然而，有关的成像技术，评估这一参数的临床效用的数据是limited.Methods和Results-Echocardiographic研究，包括多普勒组织成像（DTI）进行基因型HCM人口与P-肌球蛋白重链（β-MHC）突变。将基因型（+）LVH（G+/LVH+; n = 18）和基因型（+）无LVH（G + /LVH -; n = 18）的个体与正常对照组（n=36）进行比较。两个基因型（+）组的左心室射血分数（EF）显著更高（分别为75+/-5%和71+/-6%，对照组为64+/-5%; P
Background-Unexplained left ventricular hypertrophy (LVH) is considered diagnostic of hypertrophic cardiomyopathy (HCM) but fails to identify all genetically affected individuals. Altered diastolic function has been hypothesized to represent an earlier manifestation of HCM before the development of LVH; however, data regarding the clinical utility of imaging techniques that assess this parameter are limited.Methods and Results-Echocardiographic studies including Doppler tissue imaging (DTI) were performed in a genotyped HCM population with P-myosin heavy chain (beta-MHC) mutations. Genotype (+) individuals with LVH (G+/LVH+; n = 18) and genotype (+) individuals without LVH (G + /LVH -; n = 18) were compared with normal control subjects (n=36). Left ventricular ejection fraction (EF) was significantly higher in both genotype (+) groups (75+/-5% and 71+/-6%, respectively, versus 64+/-5% in control subjects; P