Epigenomics and breast cancer.
Epigenomics and breast cancer.
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DOI：
10.2217/14622416.9.12.1879
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发表时间：
2008-12
期刊：
影响因子：
2.1
通讯作者：
Sukumar S
中科院分区：
文献类型：
--
作者：
Lo PK;Sukumar S
乳腺癌发生涉及遗传和表观遗传改变，导致基因功能异常。表观基因组学知识的最新进展对理解导致乳腺癌的机制产生了深远的影响，并因此发展了诊断和治疗乳腺癌的新策略。已知表观遗传调控涉及三个相互作用的事件- DNA甲基化、组蛋白修饰和核小体重塑。这些过程调节染色质结构以形成常染色质或异染色质，并且反过来激活或沉默基因表达。乳腺细胞中通过异常表观遗传调控引起的关键基因表达的改变可导致癌发生的启动、促进和维持，甚至与耐药性的产生有关。我们目前审查已知的作用的表观遗传机制在乳腺癌的发展和复发。此外，我们强调了表观遗传学改变作为预测性生物标志物和抗癌治疗新靶点的重要性。
Breast carcinogenesis involves genetic and epigenetic alterations that cause aberrant gene function. Recent progress in the knowledge of epigenomics has had a profound impact on the understanding of mechanisms leading to breast cancer, and consequently the development of new strategies for diagnosis and treatment of breast cancer. Epigenetic regulation has been known to involve three mutually interacting events – DNA methylation, histone modifications and nucleosomal remodeling. These processes modulate chromatin structure to form euchromatin or heterochromatin, and in turn activate or silence gene expression. Alteration in expression of key genes through aberrant epigenetic regulation in breast cells can lead to initiation, promotion and maintenance of carcinogenesis, and is even implicated in the generation of drug resistance. We currently review known roles of the epigenetic machinery in the development and recurrence of breast cancer. Furthermore, we highlight the significance of epigenetic alterations as predictive biomarkers and as new targets of anticancer therapy.
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DOI：
10.1073/pnas.0805206105
发表时间：
2008-09-16
影响因子：
11.1
作者：
Bloushtain-Qimron, Noga;Yao, Jun;Polyak, Kornelia
通讯作者：
Polyak, Kornelia
影响因子：
9.2
作者：
Bannister, AJ;Miska, EA;Kouzarides, T
通讯作者：
Kouzarides, T
影响因子：
4.7
作者：
Ai, Lingbao;Tao, Qian;Robertson, Keith D.
通讯作者：
Robertson, Keith D.
影响因子：
30.8
作者：
Cameron, EE;Bachman, KE;Baylin, SB
通讯作者：
Baylin, SB
影响因子：
4.8
作者：
Bali, P;Pranpat, M;Bhalla, K
通讯作者：
Bhalla, K