Effect of Different Matrix Metalloproteinase Inhibitors on Microtensile Bond Strength of an Etch-and-Rinse and a Self-etching Adhesive to Dentin
Effect of Different Matrix Metalloproteinase Inhibitors on Microtensile Bond Strength of an Etch-and-Rinse and a Self-etching Adhesive to Dentin
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DOI：
10.2341/13-162-l
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发表时间：
2015-01-01
影响因子：
2.2
通讯作者：
Wiegand, A.
中科院分区：
文献类型：
--
作者：
Zheng, P.;Zaruba, M.;Wiegand, A.
目的：研究不同基质金属蛋白酶（MMP）抑制剂对蚀刻漂洗胶和自蚀刻胶陈化9个月后微拉伸结合强度（microTBS）的影响。方法和材料：用蚀刻-冲洗胶粘剂（Optibond FL）或自蚀刻胶粘剂（Clearfil SE Bond）粘合人类牙本质平面。在应用粘合剂之前，牙本质表面未经处理或用MMP抑制剂（2%二光酸氯己定[CHX]， 0.05%绿茶提取物，1mm硫酸亚铁或0.2 mM galardin）进行预处理。复合构建是增量的。预处理组在人工唾液（37℃）中储存9个月后进行测试，并与未处理组进行比较，未处理组立即（初始微tbs）和老化（9个月微tbs）进行测试。数据采用线性混合模型回归分析。失效模式分析进行微观分析，并通过重复测量方差分析进行统计学分析(p
Aim: This study aimed to analyze the effect of different matrix metalloproteinase (MMP) inhibitors on the microtensile bond strength (microTBS) of an etch-and-rinse and a self-etching adhesive after 9 months of aging.Methods and Materials: Flat human dentin surfaces were bonded either with an etch-and-rinse adhesive (Optibond FL) or a self-etching adhesive (Clearfil SE Bond). Dentin surfaces were left untreated or were pretreated with MMP inhibitors (2% chlorhexidine digluconate [CHX], 0.05% green tea extract, 1 mM ferrous sulfate, or 0.2 mM galardin) prior to application of the adhesive. Composite buildups were made incrementally. Pretreated groups were tested after 9 months of storage in artificial saliva (37 degrees C) and compared with untreated groups, which were tested immediately (initial microTBS) and upon aging (9-month microTBS). Data were analyzed by linear mixed-model regression. Failure mode analysis was performed microscopically and statistically analyzed by repeated-measures analysis of variance (p