Differences in blood pressure and vascular responses associated with ambient fine particulate matter exposures measured at the personal versus community level
Differences in blood pressure and vascular responses associated with ambient fine particulate matter exposures measured at the personal versus community level
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DOI：
10.1136/oem.2009.053991
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发表时间：
2011-03-01
影响因子：
4.9
通讯作者：
Williams, Ron
中科院分区：
文献类型：
--
作者：
Brook, Robert D.;Bard, Robert L.;Williams, Ron
背景较高的环境细颗粒物（PM2.5）水平可以与血压升高和血管dysfunctions. ObjectiveTo确定对血压和血管功能的差异影响的日常变化在社区环境与个人水平PM2.5 measurements.Methods心血管结局包括血管紧张度和功能和血压测量在65个非吸烟科目。PM2.5暴露指标包括连续5天（357次观察）测量的24小时综合个人（背心监测器）和社区环境水平。通过线性混合模型评估了社区和个人水平PM2.5暴露与心血管结局改变之间的关系。结果个人和社区PM2.5的平均每日测量值分别为21.9 +/- 24.8和15.4 +/- 7.5 μ g/m3。社区PM2.5水平与心血管结局无关。然而，个人水平的PM2.5总暴露量（TPE）增加10 μ g/m3与收缩压升高（+1.41 mm Hg;滞后第1天，p < 0.001）和个体亚组的血管收缩趋势（0.08 mm;低二手烟暴露受试者滞后第2天，p = 0.07）相关。TPE和二手烟与滞后第1天收缩压升高相关。流量介导的扩张与任何exposition.Conclusions暴露于更高的个人水平的PM2.5在日常活动中测量与低偏差和最小混杂的个人显示器与收缩压和动脉血管收缩的趋势适度增加。社区PM2.5水平的升高与这些结果无关，这表明个人和背景环境PM2.5中的特定成分可能会引起不同的心血管反应。
Background Higher ambient fine particulate matter (PM2.5) levels can be associated with increased blood pressure and vascular dysfunction.Objectives To determine the differential effects on blood pressure and vascular function of daily changes in community ambient-versus personal-level PM2.5 measurements.Methods Cardiovascular outcomes included vascular tone and function and blood pressure measured in 65 non-smoking subjects. PM2.5 exposure metrics included 24 h integrated personal- (by vest monitors) and community-based ambient levels measured for up to 5 consecutive days (357 observations). Associations between community-and personal-level PM2.5 exposures with alterations in cardiovascular outcomes were assessed by linear mixed models.Results Mean daily personal and community measures of PM2.5 were 21.9 +/- 24.8 and 15.4 +/- 7.5 mu g/m(3), respectively. Community PM2.5 levels were not associated with cardiovascular outcomes. However, a 10 mu g/m(3) increase in total personal-level PM2.5 exposure (TPE) was associated with systolic blood pressure elevation (+1.41 mm Hg; lag day 1, p < 0.001) and trends towards vasoconstriction in subsets of individuals (0.08 mm; lag day 2 among subjects with low secondhand smoke exposure, p = 0.07). TPE and secondhand smoke were associated with elevated systolic blood pressure on lag day 1. Flow-mediated dilatation was not associated with any exposure.Conclusions Exposure to higher personal-level PM2.5 during routine daily activity measured with low-bias and minimally-confounded personal monitors was associated with modest increases in systolic blood pressure and trends towards arterial vasoconstriction. Comparable elevations in community PM2.5 levels were not related to these outcomes, suggesting that specific components within personal and background ambient PM2.5 may elicit differing cardiovascular responses.