The feasibility of online genetic testing for lung cancer susceptibility: uptake of a web-based protocol and decision outcomes
The feasibility of online genetic testing for lung cancer susceptibility: uptake of a web-based protocol and decision outcomes
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DOI：
10.1097/gim.0b013e31815f8e06
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发表时间：
2008-02-01
影响因子：
8.8
通讯作者：
McBride, Colleen M.
中科院分区：
文献类型：
--
作者：
O'Neill, Suzanne C.;White, Della Brown;McBride, Colleen M.
目的：探讨通过互联网向与肺癌患者有血缘关系的吸烟者提供肺癌遗传易感性检测(GSTM1)的可行性。结果包括登录研究网站考虑测试的比例，做出登录和接受测试的知情决定的比例。方法：通过电话调查对基线措施进行评估。参与者可以选择登录研究网站；那些这样做的人会被提供测试。登录和接受测试的知情决定是通过决定结果与测试相关态度和知识之间的一致性来表示的。结果：344名亲属完成了基线访谈。116名符合条件的亲属表示有进一步的兴趣通过网络接收信息。58人登录，44人进行测试。与没有登录的人相比，那些登录的人表现出更大的戒烟动机，对癌症基因测试的认识，并且更有可能是日常互联网用户。大约一半的样本做出了明智的决定，登录并接受测试。结论：对基于网络的遗传易感性检测方案的兴趣很高。互联网提供的决策支持与其他方式一样有可能产生知情的决策。有些小组可能需要额外的支持，以改善其决策结果。
Purpose: To examine the feasibility of offering genetic susceptibility testing for lung cancer (GSTM1) via the Internet to smokers who were blood relatives of patients with lung cancer. Outcomes include proportion who logged on to the study website to consider testing, made informed decisions to log on and to be tested. Methods: Baseline measures were assessed via telephone survey. Participants could choose to log on to the study website; those who did were offered testing. Informed decisions to log on and to be tested were indicated by concordance between the decision outcome and test-related attitudes and knowledge. Results: Three hundred four relatives completed baseline interviews. One hundred sixteen eligible relatives expressed further interest in receiving information via the web. Fifty-eight logged on and 44 tested. Those logging on expressed greater quit motivation, awareness of cancer genetic testing, and were more likely to be daily Internet users than those who did not log on. Approximately half of the sample made informed decisions to log on and to be tested. Conclusion: Interest in a web-based protocol for genetic susceptibility testing was high. Internet-delivered decision support was as likely as other modalities to yield informed decisions. Some subgroups may need additional support to improve their decision outcomes.