Source distribution of neuromagnetic slow-wave activity in schizophrenic patients - effects of activation
Source distribution of neuromagnetic slow-wave activity in schizophrenic patients - effects of activation
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DOI：
10.1016/s0920-9964(02)00213-x
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发表时间：
2003-09-01
影响因子：
4.5
通讯作者：
Rockstroh, B
中科院分区：
文献类型：
--
作者：
Fehr, T;Kissler, J;Rockstroh, B
当脑电图 delta 和 theta 频率范围内的慢波在清醒状态下出现时，它们可能表明包括精神病理学在内的病理状况。可以使用磁源成像来绘制焦点慢波的发生器。由此产生的大脑图可能可以表征功能失调的大脑区域。本研究检查了 30 名精神分裂症患者和 17 名健康对照者在休息、心算和想象三种条件下 MEG 慢波密度和分布的稳定性。精神分裂症患者主要在颞叶和顶叶区域表现出较高密度的 δ 和 θ 发生器。组间差异不受特定条件的影响。使用和不使用抗精神病药物的患者之间，δ 和 θ 慢波的焦点浓度没有差异，而颞区 θ 偶极子的突出程度与抗精神病药物剂量相关。颞部慢波的相对量与阴性症状评分（PANSS-N）相关，表明颞部功能障碍可能与阴性症状有关。结果表明，在标准化环境中测量的慢波活动分布可能会增加有关精神分裂症大脑异常的诊断信息。 (C) 2002 Elsevier Science B.V. 保留所有权利。
When slow waves in the EEG delta and theta frequency range appear in the waking state, they may indicate pathological conditions including psychopathology. The generators of focal slow waves can be mapped using magnetic source imaging. The resulting brain maps may possibly characterize dysfunctional brain areas. The present study examined the stability of the density and distribution of MEG slow waves during three conditions-rest, mental arithmetic and imagery-in 30 schizophrenic patients and 17 healthy controls. Schizophrenic patients displayed a higher density of delta and theta generators primarily in temporal and parietal areas. The group difference was not affected by the particular conditions. The focal concentration of delta and theta slow waves did not differ between patients with and without neuroleptic medication, whereas the prominence of theta dipoles in the temporal area correlated with neuroleptic dosage. The relative amount of temporal slow waves was correlated with the negative symptoms score (PANSS-N) suggesting that temporal dysfunction may be related to negative symptomatology. Results suggest that the distribution of slow-wave activity, measured in a standardized setting, might add diagnostic information about brain abnormalities in schizophrenia. (C) 2002 Elsevier Science B.V. All rights reserved.