BsmI, TaqI, ApaI and Fold polymorphisms in the vitamin D receptor (VDR) gene and sisk of fracture in Caucasians: A meta-analysis
BsmI, TaqI, ApaI and Fold polymorphisms in the vitamin D receptor (VDR) gene and sisk of fracture in Caucasians: A meta-analysis
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DOI：
10.1016/j.bone.2010.06.024
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发表时间：
2010-09-01
期刊：
影响因子：
4.1
通讯作者：
Han, Zhu
中科院分区：
文献类型：
--
作者：
Ji, Guang-Rong;Yao, Meng;Han, Zhu
背景：在一些研究中，维生素 D 受体 (VDR) 基因多态性与骨矿物质密度密切相关。然而，在最近的荟萃分析中，对已发表数据的荟萃分析并未发现VDR Bsml或Taql多态性与骨折风险的关系。 目的和设计：我们的荟萃分析研究VDR基因中的Bsml、Taql、Apal和Fokl多态性与骨折风险之间是否存在关系。 数据来源：相关研究来自以下电子数据库：MEDLINE、EMBASE和2010年1月之前的Current Contents。数据综合：这项荟萃分析包括 17 项研究，总共 21 项合格比较，其中包括 2112 例骨折病例和 4521 例对照。所有这些研究都以白人为对象。所有研究的综合结果表明，骨折病例中 Bsml bb 基因型的频率显着较低[比值比 (OR) = 0.87，95% 置信区间 (Cl) = 0.76，0.98]。按骨折类型分层时，我们发现（1）髋部骨折病例中Bsinl bb基因型的频率显着较低（OR = 0.82，95% Cl =0.70，0.97）； (2) 髋部骨折病例中 Taql Tt 基因型频率显着降低 (OR = 0.65, 95% Cl = 0.43, 0.97): (3) 髋部骨折病例中 Taql tt 基因型频率显着升高 (OR= 1.74, 95% Cl = 1.05, 2.91): (4) 椎体骨折病例中 Aa 基因型频率显着升高Apal 基因型（OR= 1.63，95% CI = 1.03，2.59）。 Fold 的任何基因型均未发现显着差异。结论：我们的荟萃分析表明，Bsml bb 基因型与骨折之间存在适度但具有统计学意义的关联。 (C) 2010 Elsevier Inc. 保留所有权利。
Context: Vitamin D receptor (VDR) gene polymorphisms have been strongly associated with bone mineral density in some studies. However, in a recent meta-analysis, no relationship of the VDR Bsml or Taql polymorphism and fracture risk was found in the meta-analysis of published data.Objective and design: Our meta-analysis studied whether a relationship exists between Bsml, Taql, Apal and Fokl polymorphisms in the VDR gene and risk of fracture.Data sources: Relevant studies were identified from the following electronic databases: MEDLINE, EMBASE and Current Contents before January 2010.Data synthesis: This meta-analysis included 17 studies with a total of 21 eligible comparisons, which included 2112 fracture cases and 4521 controls. All of these studies reported on Caucasians. The combined results based on all studies showed that fracture cases had a significantly lower frequency of bb genotype of Bsml [odds ratio (OR) = 0.87, 95% confidence interval (Cl) = 0.76, 0.98]. When stratifying by fracture type, we found that (1) hip fracture cases had a significantly lower frequency of bb genotype of Bsinl (OR = 0.82, 95% Cl =0.70, 0.97); (2) hip fracture cases had a significantly lower frequency of Tt genotype of Taql (OR = 0.65, 95% Cl = 0.43, 0.97): (3) hip fracture cases had a significantly higher frequency of tt genotype of Taql (OR= 1.74, 95% Cl = 1.05, 2.91): (4) vertebral fracture cases had a significantly higher frequency of Aa genotype of Apal (OR= 1.63, 95% CI = 1.03, 2.59). No significant difference was found in any genotype of Fold.Conclusion: Our meta-analysis suggests that there is a modest but statistically significant association between the Bsml bb genotypes and fracture. (C) 2010 Elsevier Inc. All rights reserved.