Impact of environmental stress on the expression of insulin-dependent diabetes mellitus.
Impact of environmental stress on the expression of insulin-dependent diabetes mellitus.
复制标题
环境应激对胰岛素依赖型糖尿病表达的影响。
DOI：
10.1037//0735-7044.105.2.241
复制
发表时间：
1991
影响因子：
1.9
通讯作者：
Brinton,R
中科院分区：
文献类型：
--
作者：
Lehman,CD;Rodin,J;McEwen,B;Brinton,R
为了研究环境因素对遗传倾向的影响，在生物繁殖（BB）大鼠中探索了慢性环境应激对遗传决定的自身免疫性疾病的表达的影响，所述生物繁殖（BB）大鼠是人类自身免疫性胰岛素依赖型糖尿病的动物模型。随机分配到实验组的动物在14周的时间内接受了旨在模拟慢性中度压力的三重压力。对25至130日龄的动物进行称重，每周两次检测糖尿。每周对所有动物进行一次采血。根据体重减轻、2+糖尿和血糖水平250+ mg/dl诊断糖尿病。我们发现，在BB大鼠慢性应激显着增加的发病率表型表达的基因为I型糖尿病。80%的雄性压力动物和70%的雌性压力动物患上了糖尿病，而两个对照组的这一比例均为50%。强调男性发达国家的糖尿病在同一时间，其匹配的控制，而强调女性有显着延迟发病的控制。
To investigate the influence of environmental factors on inherited tendencies, the impact of chronic environmental stress on the expression of a genetically determined autoimmune disease was explored in the bio-breeding (BB) rat, which is an animal model for human autoimmune insulin-dependent diabetes mellitus. Animals assigned at random to the experimental group received a triad of stressors designed to model chronic moderate stress over a 14-week period. Animals from 25 to 130 days of age were weighed and tested for glycosuria twice weekly. Weekly blood sampling was performed on all animals. Diabetes was diagnosed on the basis of weight loss, 2+ glycosuria, and blood glucose levels of 250+ mg/dl. We found that in the BB rat chronic stress significantly increased the incidence of the phenotypic expression of the gene for Type I diabetes. Eighty percent of the male stress and 70% of the female stress animals developed diabetes, compared with 50% in both control groups. Stressed males developed manifest diabetes at the same time as their matched controls, whereas stressed females had significantly delayed onset in relation to controls.