TUMOR-CELLS SECRETE A VASCULAR-PERMEABILITY FACTOR THAT PROMOTES ACCUMULATION OF ASCITES-FLUID
TUMOR-CELLS SECRETE A VASCULAR-PERMEABILITY FACTOR THAT PROMOTES ACCUMULATION OF ASCITES-FLUID
复制标题
DOI：
10.1126/science.6823562
复制
发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
DVORAK, HF
中科院分区：
文献类型：
--
作者：
SENGER, DR;GALLI, SJ;DVORAK, HF
来自豚鼠、仓鼠和小鼠的肿瘤腹水含有能迅速增加微血管通透性的活性。这些肿瘤细胞和其他多种肿瘤细胞系在体外也分泌类似的活性。从豚鼠10号肝癌的培养基或腹水中纯化的通透性增加活性是一种34,000-42,000道尔顿蛋白，不同于其他已知的通透性因子。
Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability. Similar activity is also secreted by these tumor cell and a variety of other tumor cell lines in vitro. The permeability-increasing activity purified from either the culture medium or ascites fluid of 1 tumor, the guinea pig line 10 hepatocarcinoma, is a 34,000-42,000-dalton protein distinct from other known permeability factors.