Longitudinal diffusion changes in cerebral hemispheres after MCA infarcts
Longitudinal diffusion changes in cerebral hemispheres after MCA infarcts
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DOI：
10.1038/sj.jcbfm.9600054
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发表时间：
2005-05-01
影响因子：
6.3
通讯作者：
Chabriat, H
中科院分区：
文献类型：
--
作者：
Buffon, F;Molko, N;Chabriat, H
扩散张量成像可以在体内用于评估人类大脑中动脉（MCA）梗死后发生的纵向和区域显微结构变化。9例患者在发生孤立性MCA梗死后1周（D7）、1（M1）、3（M3）和6个月（M6）接受了研究。首先，使用每个半球的平均扩散率（MD）和各向异性分数（FA）直方图进行总体分析。此后，利用统计参数映射逐体素地研究扩散变化的区域模式99。在梗死同侧半球，直方图分析显示，D7和M6之间FA显著降低，与D7至M3 MD进行性增加相关。远离MCA区域，逐体素分析检测到M3和M6丘脑内MD显著增加，M6锥体束沿着FA减少。在对侧半球，在D7和M6之间，在没有明显的区域扩散变化的情况下，观察到与各向异性的整体降低相关的显著半球萎缩。这些结果表明，微观和宏观结构的组织修改，可以检测到与扩散张量成像在区域远离缺血区在两个半球。
Diffusion tensor imaging can be used in vivo to assess the longitudinal and regional microstructural changes occurring after middle cerebral artery (MCA) infarcts in humans. Nine patients were investigated 1 week (D7), 1 (M1), 3 (M3), and 6 months (M6) after the occurrence of an isolated MCA infarction. First, an overall analysis was performed using histograms of mean diffusivity (MD) and fractional anisotropy (FA) in each hemisphere. Thereafter, the regional pattern of diffusion changes was investigated voxel by voxel with statistical parametric mapping 99. In the hemisphere ipsilateral to the infarction, histogram analysis revealed a significant decrease in FA between D7 and M6 associated with a progressive increase in MD from D7 to M3. Remote from the MCA territory, the voxel by voxel analyses detected a significant increase in MD within the thalamus at M3 and M6 and a reduction in FA along the pyramidal tract at M6. In the contralateral hemisphere, between D7 and M6, a significant hemispheric atrophy was observed in association with a global reduction in anisotropy, in the absence of distinctive regional diffusion changes. These results suggest that micro- and macrostructural tissue modifications can be detected with diffusion tensor imaging in regions remote from the ischemic area in both hemispheres.