The contribution of intrinsic disorder prediction to the elucidation of protein function
The contribution of intrinsic disorder prediction to the elucidation of protein function
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DOI：
10.1016/j.sbi.2013.02.001
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发表时间：
2013-06-01
影响因子：
6.8
通讯作者：
Jones, David T.
中科院分区：
文献类型：
--
作者：
Cozzetto, Domenico;Jones, David T.
目前对蛋白质功能的了解主要来自于一些蛋白质结构域家族的详细表征和广泛的基于同源性的注释转移。内含子无序蛋白利用互补的分子识别机制，它们的研究有可能对该领域做出重大贡献。在已建立的计算生物学技术的基础上，现在的努力旨在揭示它们在分子和系统水平上的生物学作用。最近的事态发展确定功能位点的无序区域，并分析如何发生蛋白质紊乱的基因可以提供洞察其生化和细胞功能进行了讨论。
Current knowledge of protein function stems primarily from the detailed characterization of some protein domain families and from extensive homology-based annotation transfers. Intrinsically disordered proteins exploit complementary molecular recognition mechanisms and their study has potential to make a significant contribution to the field. Building on established computational biology techniques, efforts are now aimed at unveiling their biological roles at the molecular and system level. Recent developments towards identifying functional sites in disordered regions, and analysing how the occurrence of protein disorder in a gene can provide insight into its biochemical and cellular function are discussed.