PERSISTENT ELEVATION OF URINARY FREE CORTISOL AND LOSS OF CIRCANNUAL PERIODICITY IN RECOVERED DEPRESSIVE PATIENTS - A TRAIT FINDING
PERSISTENT ELEVATION OF URINARY FREE CORTISOL AND LOSS OF CIRCANNUAL PERIODICITY IN RECOVERED DEPRESSIVE PATIENTS - A TRAIT FINDING
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DOI：
10.1016/0165-0327(85)90036-9
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发表时间：
1985-01-01
影响因子：
6.6
通讯作者：
KATHOL, RG
中科院分区：
文献类型：
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作者：
KATHOL, RG
通过将 8 名正常受试者与 7 名在抑郁期间接受地塞米松抑制试验 (DST) 非抑制剂的康复抑郁症患者进行比较，发现了以下差异：在夏季和秋季以及当年，康复的抑郁症患者的平均尿游离皮质醇 (UFC) 水平显着高于对照组；从抑郁症中恢复的患者失去了每年一次的皮质醇排泄模式，并且贝克抑郁量表反映的抑郁症状与康复患者的 UFS 水平呈正相关，但对照组则不然。未抑制 DST 的抑郁症患者中 UFC 水平升高代表了随着时间的推移持续存在的第一个特征标记。讨论了 UFC 水平与抑郁症状之间密切关联的含义。
By comparing a group of 8 normal subjects with 7 recovered depressive patients who had been dexamethasone suppression test (DST) nonsuppressors while depressed,the following differences were identified: mean urinary free cortisol (UFC) levels were significantly higher for recovered depressive patients than for controls in the summer and fall as well as for the year; patients who had recovered from depression lost their circannual pattern of cortisol excretion and there was a positive correlation between depressive symptoms as reflected on the Beck Depression Inventory and UFS levels in recovered patients but not controls. The elevated UFC levels in depressed patients with DST nonsuppression represents the 1st trait marker which persists over time. The implications of the close association between UFC levels and depressive symptoms is discussed.