AMOXICILLIN - NEW PENICILLIN ANTIBIOTIC
AMOXICILLIN - NEW PENICILLIN ANTIBIOTIC
复制标题
DOI：
10.1128/aac.3.2.262
复制
发表时间：
1973-01-01
影响因子：
4.9
通讯作者：
TURCK, M
中科院分区：
文献类型：
--
作者：
HANDSFIELD, HH;CLARK, H;TURCK, M
阿莫西林（α-氨基-对羟基苄青霉素，BRL 2333）是一种新型半合成青霉素，其结构与氨苄西林相似，但在血清和尿液中具有更好的吸收和更高的浓度。测定了145株肠杆菌科细菌和30株铜绿假单胞菌对不同浓度阿莫西林和氨苄西林的体外敏感性。此外，测定了含有10 μg阿莫西林的圆盘周围的抑制带，并与琼脂稀释研究结果进行了比较。该药物还在38例细菌尿患者的治疗中进行了评估，这些患者接受750毫克或1克/天的剂量，持续10天。在体外，阿莫西林的活性与氨苄西林相当；大肠杆菌和奇异变形杆菌的抑菌浓度在10 μg/ml以下，而肠杆菌、克雷伯氏菌、吲哚阳性变形杆菌和假单胞菌的抑菌浓度在50 μg/ml以上。临床上，阿莫西林能有效根除由易感菌引起的菌尿，且耐受性良好。然而，就实际目的而言，阿莫西林的疗效并不比目前用于治疗急性、无并发症细菌性尿症的许多其他药物好。
Amoxicillin (α-amino-p-hydroxybenzyl penicillin, BRL 2333) is a new semisynthetic penicillin which is structurally similar to ampicillin, but which is better absorbed and yields higher concentrations in serum and urine. The in vitro susceptibility of 145 strains ofEnterobacteriaceaeand 30 isolates ofPseudomonas aeruginosawas determined against various concentrations of amoxicillin and ampicillin in agar. In addition, inhibitory zones around discs containing 10 μg of amoxicillin were measured and compared with results of agar dilution studies. The drug also was evaluated in the treatment of 38 patients with bacteriuria, who received doses of either 750 mg or 1 g/day for 10 days. In vitro, amoxicillin was comparable in activity to ampicillin; most isolates ofEscherichia coliandProteus mirabiliswere inhibited by 10 μg or less/ml, whereas the majority of strains ofEnterobacter, Klebsiella, indole-positiveProteusspecies, andPseudomonasgrew in concentrations greater than 50 μg/ml. Clinically, amoxicillin was effective in eradicating bacteriuria due to susceptible organisms and was very well tolerated. For practical purposes, however, amoxicillin performed no better than a host of other drugs presently available for the treatment of acute, uncomplicated bacteriuria.