Regulation of SPARC family proteins in disorders of the central nervous system
Regulation of SPARC family proteins in disorders of the central nervous system
复制标题
SPARC 家族蛋白在中枢神经系统疾病中的调节
DOI：
10.1016/j.brainresbull.2020.05.005
复制
发表时间：
2020-10-01
影响因子：
3.8
通讯作者：
Li, Qifu
中科院分区：
文献类型：
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作者：
Chen, Shuang;Zou, Qin;Li, Qifu
SPARC（富含半胱氨酸的酸性分泌蛋白）蛋白质家族是一类参与组织发育和修复的蛋白质，通过调节细胞粘附、增殖、转移和生长因子信号传导来影响细胞外基质（ECM）和细胞之间的相互作用。尽管在非神经组织中受到高度重视，但细胞和动物模型中的研究表明，SPARC 家族蛋白也可能继续在中枢神经系统 (CNS) 疾病和发育中发挥重要作用。这些SPARC家族蛋白在正常人的中枢神经系统中广泛表达，并且在疾病或损伤后的脑组织中显着增加，例如SPARC、SPARCL-1、FSTL-1和睾丸。在我们的综述中，我们将关注SPARC家族蛋白在自噬、细胞凋亡、血管生成、脂肪生成、炎症反应以及脑组织发育、损伤和修复中的功能，主要包括但不限于轴突再生、胶质疤痕形成、神经可塑性、神经传导相关受体的调节和神经回路的重新布线。
SPARC (secreted protein acidic and rich in cysteine) family of proteins is a class of protein involved in tissue development and repair by regulating cell adhesion, proliferation, metastasis, and growth factor signaling to affect the extracellular matrix (ECM) and interactions between cells. Although being highly valued in non-nerve tissues, studies in both cell and animal models have been revealed that SPARC family proteins may also continue to play a vital role in central nervous system (CNS) diseases and development. These SPARC family proteins are widely expressed in the CNS of normal people, and significantly increased in brain tissue following disease or injury, such as SPARC, SPARCL-1, FSTL-1 and testican. In our review, we will pay attention to the functions of SPARC family proteins in autophagy, apoptosis, angiogenesis, adipogenesis, inflammatory response, and cerebral tissue development, injury and repair mainly including but not limited to axon regeneration, formation of glial scar, neural plasticity, regulation of nerve conduction related receptors and rewiring of neural circuitry.