G protein coupled receptors in Anopheles gambiae
G protein coupled receptors in Anopheles gambiae
复制标题
DOI：
10.1126/science.1076196
复制
发表时间：
2002-10-04
期刊：
影响因子：
56.9
通讯作者：
Zwiebel, LJ
中科院分区：
文献类型：
--
作者：
Hill, CA;Fox, AN;Zwiebel, LJ
我们使用生物信息学方法从冈比亚按蚊基因组中鉴定了总共276个G蛋白偶联受体(GPCRs)。其中包括GPCRs，它们可能在影响蚊子生命周期几乎所有方面的途径中发挥作用。79个候选气味受体被鉴定为组织表达，以及76个假定的味觉受体，它们相对于果蝇黑腹果蝇的分子进化。观察到了谱系特异性基因扩展的例子，以及异常高的序列保守性的单一实例。
We used bioinformatic approaches to identify total of 276 G protein-coupled receptors (GPCRs) from the Anopheles gambiae genome. These include GPCRs that are likely to play roles in pathways affecting almost every aspect of the mosquito's life cycle. Seventy-nine candidate odorant receptors were characterized for tissue expression and, along with 76 putative gustatory receptors, for their molecular evolution relative to Drosophila melanogaster. Examples of lineage-specific gene expansions were observed as well as single instance of unusually high sequence conservation.