SLC14A1: a novel target for human urothelial cancer.
SLC14A1: a novel target for human urothelial cancer.
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DOI：
10.1007/s12094-017-1693-3
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发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
Chen G
中科院分区：
文献类型：
--
作者：
Hou R;Kong X;Yang B;Xie Y;Chen G
膀胱癌是第二常见的泌尿生殖系统恶性肿瘤。以前，已经在某些位置观察到生物分子改变，如9号染色体、视网膜母细胞瘤基因和成纤维细胞生长因子受体-3。溶质载体家族14成员1（SLC 14 A1）基因编码B型尿素转运蛋白（UT-B），该蛋白可促进尿素的被动跨膜转运，近年来被认为与人类恶性肿瘤，尤其是膀胱癌有关。本文通过对SLC 14 A1基因和UT-B蛋白特性的研究，旨在阐明SLC 14 A1在人膀胱癌中的表达行为。此外，通过回顾一些关于膀胱癌发生的成熟理论，包括一些全基因组关联研究，我们已经将癌症发展的机制与SLC 14 A1的异常表达联系起来。结论：SLC 14 A1基因在尿路上皮癌中的表达改变，可能是一个新的研究靶点。
Urinary bladder cancer is the second commonly diagnosed genitourinary malignancy. Previously, bio-molecular alterations have been observed within certain locations such as chromosome 9, retinoblastoma gene and fibroblast growth factor receptor-3. Solute carrier family 14 member 1 (SLC14A1) gene encodes the type-B urea transporter (UT-B) which facilitates the passive movement of urea across cell membrane, and has recently been related with human malignancies, especially for bladder cancer. Herein, we discussed the SLC14A1 gene and UT-B protein properties, aiming to elucidate the expression behavior of SLC14A1 in human bladder cancer. Furthermore, by reviewing some well-established theories regarding the carcinogenesis of bladder cancer, including several genome wide association researches, we have bridged the mechanisms of cancer development with the aberrant expression of SLC14A1. In conclusion, the altered expression of SLC14A1 gene in human urothelial cancer may implicate its significance as a novel target for research.
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影响因子：
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