Common oxytocin receptor gene polymorphisms and the risk for preterm birth
Common oxytocin receptor gene polymorphisms and the risk for preterm birth
复制标题
DOI：
10.1155/2013/798914
复制
发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Schmid, Maximilian
中科院分区：
文献类型：
--
作者：
Kuessel, Lorenz;Grimm, Christoph;Schmid, Maximilian
催产素对于分娩的开始和维持至关重要。我们研究了催产素受体基因多态性与早产之间的关联。使用限制性片段长度多态性基因分型，评估了 100 名早产妇女和 100 名健康妇女是否存在四种常见催产素受体基因多态性（rs2254298、rs53576、rs2228485 和 rs237911）。没有发现任何个体催产素受体基因多态性的存在与早产之间存在关联。在单倍型分析中，发现rs2254298 A等位基因、rs2228485 C等位基因和rs237911 G等位基因的单倍型组合与早产风险增加显着相关（OR = 3.2 [CI 1.04-9.8]，p = 0.043）。总之，我们的研究结果表明，三种催产素受体基因多态性的组合与早产风险增加相关。我们建议进一步研究催产素受体基因多态性和早产的作用。
Oxytocin is crucially involved in the onset and maintenance of labor. We investigated the association between oxytocin receptor gene polymorphisms and preterm birth. The presence of four common oxytocin receptor gene polymorphisms (rs2254298, rs53576, rs2228485 and rs237911) was evaluated in one hundred women with preterm birth and one hundred healthy women using restriction fragment length polymorphism genotyping. No association was found between the presence of any individual oxytocin receptor gene polymorphism and preterm birth. In haplotype analysis, the haplotype combination of rs2254298 A allele, rs2228485 C allele and rs237911 G allele was found to be significantly associated with an increased risk of preterm birth (OR = 3.2 [CI 1.04-9.8], p = 0.043). In conclusion our findings suggest that a combination of three oxytocin receptor gene polymorphisms is associated with an increased risk for preterm birth. We propose further studies investigating the role of oxytocin receptor gene polymorphisms and preterm birth.