The medial forebrain bundle of the rat. II. An autoradiographic study of the topography of the major descending and ascending components.
The medial forebrain bundle of the rat. II. An autoradiographic study of the topography of the major descending and ascending components.
复制标题
大鼠的内侧前脑束。
DOI：
10.1002/cne.902060107
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Geeraedts,LM
中科院分区：
文献类型：
--
作者：
Veening,JG;Swanson,LW;Cowan,WM;Nieuwenhuys,R;Geeraedts,LM
内侧前脑束（MFB）是一个复杂的纤维系统，部分起源于外侧视前区和外侧下丘脑区。它主要由细纤维组成，可能由多达50个不同长度和不同来源和/或目的地的下降和上升成分组成（Nieuwenhuys等人，'82）。在之前的论文（Nieuwenhuys et al.,'821）中提供的大鼠MFB和周围脑区域的图谱的帮助下，在向已知为MFB提供纤维的许多结构中注射了tritriated氨基酸后，在准备进行放射自显像的大脑中，详细分析了束的大约21个组成部分的位置和地形关系。从这个分析中可以清楚地看出，大多数标记的成分在MFB中占据特定的和相当恒定的位置。例如，上升成分主要局限于束的背侧；源自内侧视前区和各种下丘脑核的神经元相当分散地分布在大部分中脑区；来自嗅结节和大细胞视前核的下降成分被限制在束的有限部分。这些发现表明，占据下丘脑外侧区域不同部分的神经元可能接收到不同的输入，初步估计，这些输入可能主要由它们在MFB中的位置决定。在之前的论文中（Nieuwenhuys et al., 1982），根据kluver - barrre染色的制备中所见的组成纤维的大小和排列，描绘了大鼠内侧前脑束（MFB），并将其细分为多个区域。为了将正常材料中所见的纤维模式与通过外侧视前区和外侧下丘脑区下降或上升的特定纤维通路的组织联系起来，有必要研究已知有助于MFB的结构病变后退化轴突的分布，或轴突的排列
The medial forebrain bundle (MFB) is a complex fiber system that courses through and partly arises and partly terminates within the lateral preoptic and lateral hypothalamic areas. It consists mainly of thin fibers and may be comprised of as many as 50 descending and ascending components of varying lengths _and of different origins and/or destinations (Nieuwenhuys et al.,'82). With the aid of an an atlas of the MFB and the surrounding brain areas in the rat presented in the preceding paper (Nieuwenhuys et al.,'821, the position and topographic relationships of some 21 components of the bundle have been analyzed in detail, in brains that had been prepared for autoradiography following injections of tritiated amino acids into a number of structures that are known to contribute fibers to the MFB. From this analysis it is clear that most of the labeled components occupy specific and rather constant positions within the MFB. For example, the ascending components are largely confined to the dorsal half of the bundle; those arising from the medial preoptic area and the various hypothalamic nuclei are distributed rather diffusely over much of the MFB; and the descending components that arise from the olfactory tubercle and the magnocellular preoptic nucleus are confined to restricted parts of the bundle. These findings indicate that the neurons which occupy different parts of the lateral hypothalamic area probably receive distinctive inputs, and to a first approximation these are likely to be determined principally by their position within the MFB.In the preceding paper (Nieuwenhuys et al.,'82) the medial forebrain bundle (MFB) of the rat was delineated and subdivided into a number of zones on the basis of the size and arrangement of its constituent fibers as seen in Kluver-Barrera-stained preparations. In order to correlate the fiber pattern seen in normal material with the organization of specific fiber pathways that descend or ascend through the lateral preoptic and lateral hypothalamic areas, it is necessary to study either the distribution of degenerating axons after lesions of the structures that are known to contribute to the MFB, or the arrangements of