Caudate nucleus-dependent navigation strategies are associated with increased risk-taking and set-shifting behavior
Caudate nucleus-dependent navigation strategies are associated with increased risk-taking and set-shifting behavior
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DOI：
10.1101/lm.048306.118
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发表时间：
2019-04-01
影响因子：
2
通讯作者：
West, Greg L.
中科院分区：
文献类型：
--
作者：
Aumont, Etienne;Blanchette, Caroll-Ann;West, Greg L.
当人们导航时，他们使用的策略依赖于两个记忆系统之一。基于校园的空间策略包括使用多个地标来创建环境的认知地图。相比之下，尾状核为基础的反应策略是基于一系列的轮流记忆。重要的是，反应学习者在尾状核中显示出更多的灰质和功能活动，而在海马中显示出更少的灰质。与此同时，尾状核通过调节对奖励的注意力参与决策，通过调节准备行动参与定势转换。因此，本研究探讨了与尾状核和海马灰质差异相关的导航策略使用与决策和设置转换性能之间的联系。53名参与者完成了4对8虚拟迷宫、爱荷华州赌博任务（IGT）、威斯康星州卡片分类测试-64（WCST-64）和任务转换测试。结果显示，与使用校园依赖空间策略的人相比，使用反应策略的人在IGT中表现出更多的冒险行为。在WCST-64和任务转换测试中，反应策略也与增强的设置转换性能相关。这些结果证实，冒险和集转移行为，这是不同的影响尾状核和海马记忆系统，可以预测导航策略。
When people navigate, they use strategies dependent on one of two memory systems. The hippocampus-based spatial strategy consists of using multiple landmarks to create a cognitive map of the environment. In contrast, the caudate nucleus-based response strategy is based on the memorization of a series of turns. Importantly, response learners display more gray matter and functional activity in the caudate nucleus and less gray matter in the hippocampus. In parallel, the caudate nucleus is involved in decision-making by mediating attention toward rewards and in set-shifting by mediating preparatory actions. The present study, therefore, examined the link between navigational strategy use, that are associated with gray matter differences in the caudate nucleus and hippocampus, and decision-making and set-shifting performance. Fifty-three participants completed the 4 on 8 virtual maze, the Iowa Gambling Task (IGT), the Wisconsin Card Sorting Test-64 (WCST-64), and a task-switching test. The results revealed that people who use response strategies displayed increased risk-taking behavior in the IGT compared to the people using hippocampus-dependent spatial strategies. Response strategy was also associated with enhanced set-shifting performance in the WCST-64 and task-switching test. These results confirm that risk-taking and set-shifting behavior, that are differentially impacted by the caudate nucleus and hippocampus memory systems, can be predicted by navigational strategy.