Aldehyde dehydrogenase 2 polymorphism is an important gene for insulin resistance in Japanese patients with type 2 diabetes.
Aldehyde dehydrogenase 2 polymorphism is an important gene for insulin resistance in Japanese patients with type 2 diabetes.
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DOI：
10.1016/j.metop.2023.100242
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发表时间：
2023-06
期刊：
影响因子：
--
通讯作者：
Yamamoto, Kazuhiro
中科院分区：
文献类型：
--
作者：
Okura, Tsuyoshi;Nakamura, Risa;Anno, Mari;Ito, Yuichi;Kitao, Sonoko;Endo, Satomi;Taneda, Natsuka;Matsumoto, Kazuhisa;Shoji, Kyoko;Okura, Hiroko;Matsuzawa, Kazuhiko;Izawa, Shoichiro;Ueta, Etsuko;Kato, Masahiko;Imamura, Takeshi;Taniguchi, Shin-ichi;Yamamoto, Kazuhiro
关键词：
醛脱氢酶2 （ALDH2）是参与酒精代谢的重要酶。据报道，ALDH2多态性是2型糖尿病（T2DM）的一个危险因素，并且与非糖尿病个体因饮酒引起的肝脏胰岛素抵抗有关。在此，我们研究了ALDH2多态性与T2DM患者胰岛素抵抗之间的关系。我们对71名日本参与者进行了饮食耐量试验和高胰岛素-血糖钳夹：34名T2DM患者和37名非糖尿病患者。我们分析了ALDH2多态性（ALDH2 rs67）；与低危的AG、AA组相比，GG型被定义为T2DM高危组。T2DM高危组和低危组的血糖水平相似。T2DM高危组BMI （p < 0.005）、HOMA-IR胰岛素抵抗指数（p < 0.05）、胰岛素敏感性指数（p < 0.05）显著增高；然而，钳形试验中胰岛素抵抗无显著差异（p = 0.10）。两组间酒精摄入量无显著差异（p = 0.66）。非糖尿病参与者在高危组中也表现出更高的HOMA-IR胰岛素抵抗（p < 0.05），但在葡萄糖钳试验中胰岛素抵抗水平（p = 0.56）和胰岛素分泌没有显著性。结果表明，ALDH2是与日本2型糖尿病患者胰岛素抵抗和肥胖相关的重要基因。
Aldehyde dehydrogenase 2 (ALDH2) is an important enzyme involved in alcohol metabolism. ALDH2 polymorphism has been reported as a risk factor for type 2 diabetes mellitus (T2DM) and is associated with liver insulin resistance due to alcohol consumption in non-diabetic individuals. Herein, we investigated the association between ALDH2 polymorphisms and insulin resistance in patients with T2DM. We performed a meal tolerance test and the hyperinsulinemic-euglycemic clamp on 71 Japanese participants: 34 patients with T2DM, and 37 non-diabetic participants. We analyzed the ALDH2 polymorphism (ALDH2 rs67); GG type was defined as the T2DM high-risk group, compared with the low-risk AG and AA groups. Glucose levels were similar in the high- and low-risk T2DM groups. The high-risk group for T2DM showed a significantly higher BMI (p < 0.005), insulin resistance in HOMA-IR (p < 0.05), and Insulin sensitivity index (p < 0.05); however, there were no significant differences in insulin resistance in the clamp test (p = 0.10). Alcohol consumption did not differ significantly between groups (p = 0.66). Non-diabetic participants also showed higher HOMA-IR insulin resistance in the high-risk group (p < 0.05), but insulin resistance levels in the glucose clamp tests (p = 0.56) and insulin secretion were not significant. The results suggest that ALDH2 is an important gene associated with insulin resistance and obesity in Japanese patients with type 2 diabetes.
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