Carbon monoxide releasing molecules: New insights for anticoagulation strategy in sepsis
Carbon monoxide releasing molecules: New insights for anticoagulation strategy in sepsis
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DOI：
10.1007/s00018-008-8487-2
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发表时间：
2009-02
影响因子：
8
通讯作者：
B. Sun;X. Chen
中科院分区：
文献类型：
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作者：
B. Sun;X. Chen
脓毒症是一种常见且严重的疾病，由出血、创伤或腹部手术引起。尽管在治疗方面有了新的理解和很大的进步，特别是干扰了一个有趣的靶点，但脓毒症仍然是重症患者死亡的主要原因。已经研究了各种治疗方法，但大多数治疗方法在临床试验中都失败了。很明显，所有败血症患者都表现出凝血功能异常。这些异常从轻微的凝血系统激活到明显的激活，最终发展为暴发性DIC。研究证实，一氧化碳具有重要的细胞保护作用和抗炎作用。到目前为止，在脓毒症期间一氧化碳是否在改善凝血系统从而降低死亡率方面发挥了关键作用的问题还没有得到明确的回答。试图证实这一策略可能会在脓毒症的治疗研究和这种疾病的新药物的开发方面带来新的方向。
Sepsis is a common and serious medical condition caused by hemorrhage, trauma, or abdominal surgery. Despite new understanding and much progress in therapies that specifically interfere with an interesting target, sepsis remains the leading causes of death in critically ill patients. Various therapies have been studied, but the majority of these treatments fail in clinical trials. It is clear that all septic patients exhibit coagulation abnormalities. These abnormalities range from subtle to marked activation of coagulation system, and finally to fulminant DIC. Studies confirmed that carbon monoxide has important cytoprotective function and anti-inflammatory properties. Until now, the question of whether CO plays a critical role in improving the coagulation system and then decreasing mortality during sepsis has not yet been definitely answered. Attempts to confirm this strategy may lead to new directions in the study of treatment of sepsis and the development of a novel agent for this disorder.