Progesterone prevents depression-like behavior in a model of Parkinson's disease induced by 6-hydroxydopamine in male rats
Progesterone prevents depression-like behavior in a model of Parkinson's disease induced by 6-hydroxydopamine in male rats
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DOI：
10.1016/j.pbb.2011.06.012
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发表时间：
2011-10-01
影响因子：
3.6
通讯作者：
Yunes, Roberto
中科院分区：
文献类型：
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作者：
Casas, Sebastian;Garcia, Sebastian;Yunes, Roberto
左侧纹状体注射 6-羟基多巴胺 (6-OHDA) 诱导的偏侧帕金森症是公认的大鼠运动缺陷模型。一些有关运动缺陷的报告表明，偏侧帕金森病动物对类固醇给药有良好的反应。然而，没有太多关于黄体酮给药与认知和情感功能障碍相关的信息。在这里，我们可以证实先前的报告，即注射 6-OHDA 4 周后出现轻度记忆缺陷和明显的抑郁样行为。我们还提供了一些证据，表明在注射 6-OHDA 7 天后服用黄体酮可能是一种可能的神经保护剂，涉及运动缺陷以及认知、记忆和抑郁样行为。通过服用三环类抗抑郁药丙咪嗪，情感缺陷得以恢复。由于帕金森病是人类心理机能衰退的一个明显原因，因此能够尽早处理非运动指标，以便使用前瞻性神经保护剂来预防疾病的进展，这一点非常重要。 (C) 2011 Elsevier Inc. 保留所有权利。
Hemiparkinsonism induced by 6-hydroxydopamine (6-OHDA) injected in left corpus striatum is a recognized model of motor deficits in rats. Some reports concerning motor deficits indicate a favorable response to steroid administration in hemiparkinsonian animals. However, there is no much information regarding progesterone administration in relation to cognitive and affective dysfunctions. Here we could confirm earlier reports regarding a mild deficit of memory and a noticeable depressive-like behavior 4 weeks after injecting 6-OHDA. We also present some evidence that progesterone could be - when administered 7 days after the injection of 6-OHDA - a possible neuroprotector concerning both motor deficits as well as cognitive - memory- and depression-like behaviors. The affective deficit was reverted by administering the tricyclic antidepressant imipramine. Since Parkinson's disease is a conspicuous cause of psycho-organic decline in human beings, it would be important to be able of dealing early with non-motor indicators in order to use prospective neuroprotectors to prevent the progression of the disease. (C) 2011 Elsevier Inc. All rights reserved.