Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis.
Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis.
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DOI：
10.1016/j.carpath.2012.06.006
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
García-Cardeña G
中科院分区：
文献类型：
--
作者：
Gimbrone MA Jr;García-Cardeña G
在人类和实验动物中，动脉粥样硬化病变的形成定位于与某些动脉几何形状相关的血流紊乱区域，表明血流动力学在动脉粥样硬化的病理生物学中起着重要作用。越来越多的证据表明，直接暴露于搏动血流产生的各种流体力学力的血管内皮可以区分这些不同的生物力学刺激，并将其转化为调节内皮功能的遗传调控程序。在这篇简短的综述中，我们讨论了血流产生的生物力学刺激如何影响内皮功能表型，并探讨了“动脉粥样硬化”血液动力学环境作为动脉粥样硬化发生的“局部危险因素”的工作假设。此外，我们考虑了“动脉粥样硬化保护基因”的激活及其在血管稳态中作为“关键调节节点”的作用的治疗意义。
The localization of atherosclerotic lesion formation to regions of disturbed blood flow associated with certain arterial geometries, in humans and experimental animals, suggests an important role for hemodynamic forces in the pathobiology of atherosclerosis. There is increasing evidence that the vascular endothelium, which is directly exposed to various fluid mechanical forces generated by pulsatile blood flow, can discriminate among these different biomechanical stimuli and transduce them into genetic regulatory programs that modulate endothelial function. In this brief review, we discuss how biomechanical stimuli generated by blood flow can influence endothelial functional phenotypes, and explore the working hypothesis of “atheroprone” hemodynamic environments as “local risk factors” in atherogenesis. In addition, we consider the therapeutic implications of the activation of “atheroprotective genes” and their role as “critical regulatory nodes” in vascular homeostasis.
影响因子：
4.4
作者：
Comander J;Natarajan S;Gimbrone MA Jr;García-Cardeña G
通讯作者：
García-Cardeña G