Visual-biased frontal structures are preferentially connected to multisensory working memory regions.
Visual-biased frontal structures are preferentially connected to multisensory working memory regions.
复制标题
视觉偏向的额叶结构优先连接到多感觉工作记忆区域。
DOI：
10.1167/19.10.245c
复制
发表时间：
2019
影响因子：
1.8
通讯作者：
Somers, David C.
中科院分区：
文献类型：
--
作者：
Noyce, Abigail;Lefco, Ray W.;Brissenden, James A.;Tobyne, Sean M.;Shinn-Cunningham, Barbara G.;Somers, David C.
侧额叶皮层包含以感觉特异性方式被招募用于工作记忆（WM）的离散区域。我们收集了块设计的功能磁共振成像（TE= 30毫秒，TR= 2000毫秒，1毫米ISO），而15名受试者进行2回WM视觉（面部照片）和听觉（猫/狗发声）刺激。还收集感觉运动控制块。此外，我们收集了2-3个运行（180 TR）的睁眼休息状态fMRI的每一个主题。直接对比视觉工作记忆和听觉工作记忆的激活，发现个体中央前沟和额下沟沿着有6个双侧感觉偏向结构。上级和下级中央前沟（sPCS和iPCS）和中额下沟（midIFS）中的视觉偏向结构与横回交叉中央前沟（tgPCS）、尾侧额下沟（cIFS）和额盖（FO）中的视觉偏向结构交错。每个个体受试者的视觉和认知偏向的额叶区域作为种子到全脑静息状态功能连接分析的种子。在对生成的映射进行阈值处理以去除负相关性后，我们计算了每个皮质顶点与视觉和神经偏向区域的连接差异（Tobyne 2017）。这种差异连接分析揭示了我们先前确定为候选多感觉WM区域的区域内的细分（Noyce 2017）。前额叶（AIC）包含一个优先连接到额叶听觉结构的尾侧部分和一个优先连接到额叶视觉结构的吻侧部分。类似地，前辅助运动区（pre-supplementary motor area，preSMA）包含一个优先视觉连接的区域，其上下两侧是优先听觉连接的区域。评估这些区域的任务激活表明，前SMA和AIC的视觉连接部分在两个WM任务中显著且相等地被招募，而视觉连接部分在两个任务中均未被招募。这些结果提供了进一步的证据，人类的视觉认知皮层机制灵活地参与了广泛的任务。
Lateral frontal cortex contains discrete regions that are recruited for working memory (WM) in sensory-specific ways. We collected block-design fMRI (TE= 30 ms, TR= 2000 ms, 1 mm iso) while 15 subjects performed 2-back WM for visual (face photographs) and auditory (cat/dog vocalizations) stimuli. Sensorimotor control blocks were also collected. In addition, we collected 2–3 runs (180 TRs each) of eyes-open resting-state fMRI for each subject. Directly contrasting visual WM task activation with auditory WM revealed 6 bilateral sensory-biased structures along the precentral sulcus and inferior frontal sulcus of individual subjects. Visual-biased structures in the superior and inferior precentral sulcus (sPCS and iPCS) and mid inferior frontal sulcus (midIFS) are interleaved with auditory-biased structures in the transverse gyrus intersecting precentral sulcus (tgPCS), caudal inferior frontal sulcus (cIFS), and frontal operculum (FO). Each individual subject’s visual-and auditory-biased frontal regions served as seeds in a seed-to-whole-brain resting-state functional connectivity analysis. After thresholding the resulting maps to remove negative correlations, we computed the difference in connectivity to the visual-and auditory-biased regions for each cortical vertex (Tobyne 2017). This differential connectivity analysis revealed subdivisions within areas we had previously identified as candidate multi-sensory WM regions (Noyce 2017). Anterior insula (AIC) contains a caudal portion with preferential connectivity to frontal auditory structures, and a more rostral portion with preferential connectivity to frontal visual structures. Similarly, pre-supplementary motor area (preSMA) contains a region with preferential visual connectivity, flanked above and below by regions with preferential auditory connectivity. Assessing task activation in these regions showed that the visual-connected portions of preSMA and AIC are significantly and equally recruited in both WM tasks, while the auditory-connected portions are not recruited in either task. These results provide further evidence that human cortical mechanisms for visual cognition participate flexibly in a wide range of tasks.