Recent developments in the anemia of chronic disease.
Recent developments in the anemia of chronic disease.
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发表时间：
2003-03
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通讯作者：
R. Means
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作者：
R. Means
慢性病性贫血（ACD）是一种低增殖性贫血，其定义为在存在足够的网状内皮铁储备的情况下血清或血浆铁浓度低。已经确定ACD是由介导免疫或炎症反应的细胞因子的作用引起的。在过去的3年中，这种综合征的临床范围已扩大到传统的慢性感染性、炎症性或肿瘤性疾病之外，包括其他通常是急性的综合征，其中有相同的发病机制。对可溶性转铁蛋白受体浓度在临床医学中的应用的进一步理解增强了诊断ACD的能力，并且在严重受影响的ACD患者的管理中使用重组人促红细胞生成素的进一步经验为合理和有效的管理提供了基础。目前正在进行的关于ACD发生机制的研究继续阐明这种常见且具有临床意义的综合征的发病机制。
The anemia of chronic disease (ACD) is a hypoproliferative anemia defined by a low serum or plasma iron concentration in the presence of adequate reticuloendothelial iron stores. It is been established that ACD results from the effects of cytokines that mediate the immune or inflammatory response. During the past 3 years, the clinical scope of this syndrome has been expanded beyond the traditional chronic infectious, inflammatory, or neoplastic diseases to include other, often acute, syndromes in which the same pathogenetic mechanisms are operating. An improved understanding of the use of the soluble transferrin receptor concentration in clinical medicine has enhanced the ability to diagnose ACD, and further experience with the use of recombinant human erythropoietin in the management of severely affected patients with ACD has provided a basis for rational and effective management. Ongoing studies of the mechanisms contributing to the development of ACD continue to elucidate the pathogenesis of this common and clinically significant syndrome.