eEF1A1 Overexpression Enhances Tumor Progression and Indicates Poor Prognosis in Hepatocellular Carcinoma.
eEF1A1 Overexpression Enhances Tumor Progression and Indicates Poor Prognosis in Hepatocellular Carcinoma.
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eEF1A1 过度表达会促进肝细胞癌的肿瘤进展并表明预后不良
DOI：
10.1016/j.tranon.2017.11.001
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发表时间：
2018-03
影响因子：
5
通讯作者：
Yun JP
中科院分区：
文献类型：
--
作者：
Chen SL;Lu SX;Liu LL;Wang CH;Yang X;Zhang ZY;Zhang HZ;Yun JP
肝脏是生理上蛋白质生产的主要贡献者。蛋白质合成的异常状态导致肿瘤进展。真核细胞延伸因子1 α 1（eEF 1A 1）是调节蛋白质合成的真核细胞延伸因子家族的主要成员。虽然eEF 1A 1在控制细胞命运中起着重要作用，但其在肿瘤发生和进展中的临床意义尚未报道。本研究旨在探讨eEF 1A 1在肝细胞癌（HCC）中的表达及其预后意义。我们的数据表明，eEF 1A 1表达升高，在肝癌细胞系和临床样品在mRNA和蛋白质水平。免疫组化显示，eEF 1A 1表达上调，在肝癌样品相比，相应的非肿瘤组织。在50例肝癌伴门静脉癌栓患者中，癌转移灶中eEF 1A 1免疫反应性高于原发灶。Kaplan-Meier分析表明，在453例HCC患者中，eEF 1A 1表达增加与术后总体和无病生存率不利密切相关。此外，多变量分析表明eEF 1A 1是总生存期和无病生存期的独立预测因子。总的来说，我们的研究表明eEF 1A 1作为一种新的预后生物标志物和HCC患者的潜在治疗靶点。
Liver is a major contributor of protein production physiologically. The aberrant state of protein synthesis leads to tumor progression. Eukaryotic elongation factor 1 alpha 1 (eEF1A1) is a major member of the eukaryotic elongation factor family that regulates protein synthesis. Although eEF1A1 plays an essential role in controlling the cell fate, its clinical significance in tumor development and progression has not been reported. Here, we aimed to uncover the expression and prognostic significance of eEF1A1 in hepatocellular carcinoma (HCC). Our data indicated that eEF1A1 expression was elevated in HCC cell lines and clinical samples at both the mRNA and protein levels. Immunohistochemistry revealed that eEF1A1 expression was upregulated in HCC samples compared with corresponding non-tumorous tissues. In 50 HCC cases with portal vein embolus, higher eEF1A1 immunoreactivity was detected in tumor metastases compared with the primary lesions. Kaplan–Meier analysis indicated that increased eEF1A1 expression was closely associated with unfavorable post-surgical overall and disease-free survival in 453 HCC patients. Moreover, multivariate analysis indicated eEF1A1 as an independent predictor for overall and disease-free survival. Collectively, our study suggests eEF1A1 as a novel prognostic biomarker and potential therapeutic target for HCC patients.
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影响因子：
7.7
作者：
Vera M;Pani B;Griffiths LA;Muchardt C;Abbott CM;Singer RH;Nudler E
通讯作者：
Nudler E
影响因子：
3.7
作者：
Blanch A;Robinson F;Watson IR;Cheng LS;Irwin MS
通讯作者：
Irwin MS
影响因子：
13.5
作者：
Giannini, Edoardo G.;Farinati, Fabio;Trevisani, Franco
通讯作者：
Trevisani, Franco
影响因子：
7.3
作者：
Sasikumar, Arjun N.;Perez, Winder B.;Kinzy, Terri Goss
通讯作者：
Kinzy, Terri Goss
P21激活激酶4结合翻译延伸因子eEF1A1促进胃癌细胞迁移和侵袭
影响因子：
4.2
作者：
Li, Xiang;Li, Jiabin;Li, Feng
通讯作者：
Li, Feng