Genomic Characterization of VIM Metallo-β-Lactamase-Producing Alcaligenes faecalis from Gaza, Palestine
Genomic Characterization of VIM Metallo-β-Lactamase-Producing Alcaligenes faecalis from Gaza, Palestine
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DOI：
10.1128/aac.01499-17
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发表时间：
2017-11-01
影响因子：
4.9
通讯作者：
Chen, Liang
中科院分区：
文献类型：
--
作者：
Al Laham, Nahed;Chavda, Kalyan D.;Chen, Liang
产碳青霉烯酶的革兰氏阴性菌（CP-GNB）在全球范围内的传播越来越广泛，并且在各种细菌种属中已鉴定出不同的碳青霉烯酶家族。在这里，我们报告了五个Vim金属β-内酰胺酶生产粪产碱杆菌分离株与一个小爆发在加沙，巴勒斯坦的一家大医院。新一代测序分析表明，bla（Vim-2）在三个菌株中由染色体基因组岛携带，而bla（Vim-4）在两个菌株中由新质粒携带。
Carbapenemase-producing Gram-negative bacteria (CP-GNB) have increasingly spread worldwide, and different families of carbapenemases have been identified in various bacterial species. Here, we report the identification of five VIM metallo-beta-lactamase-producing Alcaligenes faecalis isolates associated with a small outbreak in a large hospital in Gaza, Palestine. Next-generation sequencing analysis showed bla(VIM-2) is harbored by a chromosomal genomic island among three strains, while bla(VIM-4) is carried by a novel plasmid in two strains.