CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response
CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response
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DOI：
10.1038/nsmb1277
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发表时间：
2007-08-01
影响因子：
16.8
通讯作者：
Chen, Junjie
中科院分区：
文献类型：
--
作者：
Kim, Hongtae;Huang, Jun;Chen, Junjie
乳腺癌1号基因（BRCA1）的产物通过与许多蛋白质相互作用，包括与BACH1、CtIP和RAP80相互作用，在DNA损伤应答中起着至关重要的作用。在此我们鉴定出一种含卷曲螺旋结构域的蛋白质CCDC98是一种与BRCA1相互作用的蛋白质。CCDC98与BRCA1共定位，并且是电离辐射后形成BRCA1焦点所必需的。此外，与BRCA1一样，CCDC98在辐射敏感性和损伤诱导的G2/M检查点控制中起作用。总之，这些结果表明CCDC98是参与哺乳动物DNA损伤应答的BRCA1功能的一种介质。
The product of the breast cancer-1 gene, BRCA1, plays a crucial part in the DNA damage response through its interactions with many proteins, including BACH1, CtIP and RAP80. Here we identify a coiled-coil domain-containing protein, CCDC98, as a BRCA1-interacting protein. CCDC98 colocalizes with BRCA1 and is required for the formation of BRCA1 foci in response to ionizing radiation. Moreover, like BRCA1, CCDC98 has a role in radiation sensitivity and damage-induced G2/M checkpoint control. Together, these results suggest that CCDC98 is a mediator of BRCA1 function involved in the mammalian DNA damage response.