Maternal diet during pregnancy and its association with medulloblastoma in children: A Children's Oncology Group study (United States)
Maternal diet during pregnancy and its association with medulloblastoma in children: A Children's Oncology Group study (United States)
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DOI：
10.1007/s10552-005-3144-7
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发表时间：
2005-09-01
影响因子：
2.3
通讯作者：
Cnaan, A
中科院分区：
文献类型：
--
作者：
Bunin, GR;Kushi, LH;Cnaan, A
怀孕期间的水果，蔬菜，维生素C和叶酸被认为是髓母细胞瘤/原始神经外胚层肿瘤（PNET）的保护因素，PNET是一种常见的儿童脑肿瘤。作者试图复制这些发现，并调查饮食的其他方面。对315例6岁以下诊断病例的母亲和315例对照组的母亲进行了关于孕期饮食的访谈。作者观察到水果/果汁与维生素C （OR = 0.6, 95%可信区间（CI）： 0.3, 1.1）之间存在适度的负相关（OR = 0.6, 95%可信区间：0.4,1.1）。与之前的研究相反，叶酸和蔬菜没有关联。正如假设的那样，与其他儿童脑肿瘤相比，腌肉与成神经管细胞瘤/PNET无关。与非新鲜桃子和类似水果的负相关（OR = 0.5, 95% CI: 0.3, 0.8）和与非巧克力糖果的正相关（OR = 1.7, 95% CI: 1.0, 3.0）重复了先前的研究结果。炸薯条（OR = 2.4, 95% CI: 1.2, 4.9）和辣椒（OR = 1.8, 95% CI: 1.0, 3.0）与成神经管细胞瘤/PNET相关。结果表明，饮食的某些方面值得进一步研究。
Fruit, vegetables, vitamin C, and folate during pregnancy have been suggested as protective factors for medulloblastoma/primitive neuroectodermal tumor (PNET), a common brain tumor in children. The authors sought to replicate these findings and investigate other aspects of diet. Mothers of 315 cases under age six at diagnosis and 315 controls were interviewed about their pregnancy diet. The authors observed modest, inverse associations for fruits/juices (odds ratio (OR) for highest compared to lowest category = 0.6, 95% confidence interval (CI): 0.3, 1.1) and vitamin C (OR = 0.6, 95% CI: 0.4, 1.1). In contrast to the previous study, folate and vegetables showed no association. As hypothesized, cured meats were not associated with medulloblastoma/PNET, in contrast to other childhood brain tumors. An inverse association with nonfresh peaches and similar fruits (OR = 0.5, 95% CI: 0.3, 0.8) and a positive association with nonchocolate candy (OR = 1.7, 95% CI: 1.0, 3.0) replicated previous findings. French fries (OR = 2.4, 95% CI: 1.2, 4.9) and chili peppers (OR = 1.8, 95% CI: 1.0, 3.0) were associated with medulloblastoma/PNET. The results suggest that some aspects of diet are worthy of further research.