Uveitis in Behcet disease: An analysis of 880 patients.
Uveitis in Behcet disease: An analysis of 880 patients.
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DOI：
10.1016/j.ajo.2004.03.022
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发表时间：
2004-09-01
影响因子：
4.2
通讯作者：
Urgancioglu, M
中科院分区：
文献类型：
--
作者：
Tugal-Tutkun, I;Onal, S;Urgancioglu, M
目得：我们的目的是描述人口统计学和临床特征，眼部表现，并发症，视力预后，并在土耳其白塞葡萄膜炎患者的大人口的治疗。我们还旨在比较男性和女性之间以及1990年之前和之后出现的患者之间的视力预后。设计：观察性病例系列。方法：回顾性研究880例连续患者（1,567只眼），从1980年到1998年，在伊斯坦布尔大学伊斯坦布尔医学院眼科葡萄膜炎服务部就诊。所有患者均符合白塞病国际研究组的分类标准。患者的性别，年龄在葡萄膜炎发病，眼部特征，眼部并发症，视力，和系统的treatmentcovered.RESULTS：590，9例（68%）为男性和281（32%）为女性。葡萄膜炎发病的平均年龄男性为28.5岁，女性为30岁。78.1%的患者双眼受累，21.9%的患者单侧受累。全葡萄膜炎是男女中最常见的形式。眼底病变以及威胁视力的并发症在男性中更常见。在随访开始时，男性30.9%的眼睛和女性24.2%的眼睛的潜在视力为0.1或更低。Kaplan-Meier生存分析估计男性和女性在5年和10年时丧失有用视力（>0.1）的风险分别为21%和10%以及30%和17%。结论：白塞葡萄膜炎好发于30岁左右，且男性发病率较高。这种疾病更严重，男性失去有用视力的风险高于女性。然而，这种风险在1990年代已大大降低。(C)2004年，Elsevier Inc. All rights reserved.
PURPOSE: We aimed to describe the demographic and clinical features, ocular manifestations, complications, visual prognosis, and treatment in a large population of Turkish patients with Behcet uveitis. We also aimed to compare visual prognosis between male and female sex and between patients who presented before and after 1990.DESIGN: Observational case series.METHODS: A retrospective study of 880 consecutive patients (1,567 eyes) with Behcet uveitis seen at the Uveitis Service, Department of Ophthalmology, Istanbul Faculty of Medicine, Istanbul University, from 1980 to 1998. All patients met the classification criteria of the International Study Group for Behcet's Disease. Information on the patient's sex, age at onset of uveitis, ocular features, ocular complications, visual acuity, and systemic treatment was collected.RESULTS: Five hundred ninety,nine patients (68%) were male and 281 (32%) were female. The mean age at onset of uveitis was 28.5 years in male and 30 years in female patients. Ocular involvement was bilateral in 78.1% and unilateral in 21.9% of the patients. Panuveitis was the most common form in both sexes. Fundus lesions as well as sight-threatening complications were more common in males. At the beginning of the follow-up, potential-visual acuity was 0.1 or less in 30.9% of eyes in males and 24.2% of eyes in females. Kaplan-Meier survival analysis estimated the risks of losing useful vision (>0.1) at 5 and 10 years for males and females as 21% vs 10% and 30% vs 17%, respectively. Male patients who presented in the 1990s had a significantly lower risk of losing vision compared with male patients who presented in the 1980s.CONCLUSION: Behcet uveitis starts frequently around the end of the third decade and has a male predominance. The disease is more severe and the risk of losing useful vision is higher in males than in females. However, this risk has been significantly reduced in the 1990s. (C) 2004 by Elsevier Inc. All rights reserved.