Medication Adherence After Acute Coronary Syndrome in Women Compared With Men: A Systematic Review and Meta-Analysis.
Medication Adherence After Acute Coronary Syndrome in Women Compared With Men: A Systematic Review and Meta-Analysis.
复制标题
DOI：
10.3389/fgwh.2021.637398
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Peters SAE
中科院分区：
文献类型：
--
作者：
Bots SH;Inia JA;Peters SAE
引言：药物治疗是急性冠脉综合征（ACS）幸存者二级预防的重要组成部分。然而，坚持药物治疗方案往往是次优的，降低了治疗的有效性。有研究表明，性别会影响心血管药物的依从性，但研究结果各不相同，缺乏系统的概述。方法：我们于2019年10月16日对PubMed和EMBASE进行了系统检索。纳入了报告ACS患者对一种或多种特定药物类别的性别特异性依从性的研究。按药物类别提取比值比或等效值，并使用随机效应模型进行合并。结果：我们总共纳入了28项研究，其中一些研究有不止一个药物组的依从性数据。有7项关于血管紧张素转换酶抑制剂（ACEI）或血管紧张素II受体阻滞剂（ARB）的研究（n = 100，909，37%女性），8项抗血小板药物研究（n = 37，804，27%女性），11项β受体阻滞剂研究（n = 191，339，38%女性），17项降脂药物研究（n = 318，837，35%女性）。女性对降脂药物的依从性低于男性（OR = 0.87，95%CI 0.82-0.92），但抗血小板药物治疗未观察到这种性别差异（OR = 0.95，95% CI 0.83-1.09）、ACEIs/ARB（OR = 0.95，95% CI 0.78-1.17）或β受体阻滞剂（OR = 0.97，95% CI 0.86-1.11）。结论：女性ACS患者对降脂药物的依从性差于男性。女性和男性ACS患者在抗血小板药物、ACEI/ARB和β受体阻滞剂的依从性方面无差异。
Introduction: Pharmacological treatment is an important component of secondary prevention in acute coronary syndrome (ACS) survivors. However, adherence to medication regimens is often suboptimal, reducing the effectiveness of treatment. It has been suggested that sex influences adherence to cardiovascular medication, but results differ across studies, and a systematic overview is lacking. Methods: We performed a systematic search of PubMed and EMBASE on 16 October 2019. Studies that reported sex-specific adherence for one or more specific medication classes for ACS patients were included. Odds ratios, or equivalent, were extracted per medication class and combined using a random effects model. Results: In total, we included 28 studies of which some had adherence data for more than one medication group. There were 7 studies for angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) (n = 100,909, 37% women), 8 studies for antiplatelet medication (n = 37,804, 27% women), 11 studies for beta-blockers (n = 191,339, 38% women), and 17 studies for lipid-lowering medication (n = 318,837, 35% women). Women were less adherent to lipid-lowering medication than men (OR = 0.87, 95% CI 0.82–0.92), but this sex difference was not observed for antiplatelet medication (OR = 0.95, 95% CI 0.83–1.09), ACEIs/ARBs (OR = 0.95, 95% CI 0.78–1.17), or beta-blockers (OR = 0.97, 95% CI 0.86–1.11). Conclusion: Women with ACS have poorer adherence to lipid-lowering medication than men with the same condition. There are no differences in adherence to antiplatelet medication, ACEIs/ARBs, and beta-blockers between women and men with ACS.
登录
查看更多内容
DOI：
10.1055/s-0038-1676529
发表时间：
2018-10-01
期刊：
TH open : companion journal to thrombosis and haemostasis
影响因子：
--
作者：
Degli Esposti, Luca;Perrone, Valentina;Rossini, Roberta
通讯作者：
Rossini, Roberta
影响因子：
168.9
作者：
Mihaylova, B.;Emberson, J.;Blackwell, L.;Keech, A.;Simes, J.;Barnes, E. H.;Voysey, M.;Gray, A.;Collins, R.;Baigent, C.;de Lemos, J.;Braunwald, E.;Blazing, M.;Murphy, S.;Downs, J. R.;Gotto, A.;Clearfield, M.;Holdaas, H.;Gordon, D.;Davis, B.;Koren, M.;Dahlof, B.;Poulter, N.;Sever, P.;Knopp, R. H.;Fellstrom, B.;Holdaas, H.;Jardine, A.;Schmieder, R.;Zannad, F.;Goldbourt, U.;Kaplinsky, E.;Colhoun, H. M.;Betteridge, D. J.;Durrington, P. N.;Hitman, G. A.;Fuller, J.;Neil, A.;Wanner, C.;Krane, V.;Sacks, F.;Moye, L.;Pfeffer, M.;Hawkins, C. M.;Braunwald, E.;Kjekshus, J.;Wedel, H.;Wikstrand, J.;Barter, P.;Keech, A.;Tavazzi, L.;Maggioni, A.;Marchioli, R.;Tognoni, G.;Franzosi, M. G.;Maggioni, A.;Bloomfield, H.;Robins, S.;Collins, R.;Armitage, J.;Keech, A.;Parish, S.;Peto, R.;Sleight, P.;Pedersen, T. R.;Ridker, P. M.;Holman, R.;Meade, T.;Simes, J.;Keech, A.;MacMahon, S.;Marschner, I.;Tonkin, A.;Shaw, J.;Serruys, P. W.;Nakamura, H.;Knatterud, G.;Furberg, C.;Byington, R.;Macfarlane, P.;Cobbe, S.;Ford, I.;Murphy, M.;Blauw, G. J.;Packard, C.;Shepherd, J.;Kjekshus, J.;Pedersen, T.;Wilhelmsen, L.;Braunwald, E.;Cannon, C.;Murphy, S.;Collins, R.;Armitage, J.;Bowman, L.;Parish, S.;Peto, R.;Sleight, P.;Baigent, C.;Landray, M.;Collins, R.;La Rosa, J.;Rossouw, J.;Probstfield, J.;Shepherd, J.;Cobbe, S.;Macfarlane, P.;Ford, I.
通讯作者：
Ford, I.
影响因子：
--
作者：
Ho, P. Michael;Spertus, John A.;Rumsfeld, John S.
通讯作者：
Rumsfeld, John S.
影响因子：
24
作者：
Colantonio, Lisandro D.;Huang, Lei;Rosenson, Robert S.
通讯作者：
Rosenson, Robert S.
影响因子：
4
作者：
Alsabbagh, Mhd. Wasem;Eurich, Dean;Blackburn, David F.
通讯作者：
Blackburn, David F.