Effect of arotinolol on hemodynamics and plasma atrial natriuretic peptide at rest and during stress in spontaneously hypertensive rats.
Effect of arotinolol on hemodynamics and plasma atrial natriuretic peptide at rest and during stress in spontaneously hypertensive rats.
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阿罗洛尔对自发性高血压大鼠静息和应激期间血流动力学和血浆心房钠尿肽的影响。
DOI：
10.3109/10641968909038175
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
M. Nakai
中科院分区：
文献类型：
--
作者：
J. Yamamoto;H. Matsubara;M. Nakai
我们研究了青蒿素慢性治疗对自发性高血压（SHR）和Wistar-Kyoto （WKY）大鼠静息和应激时血液动力学和血浆儿茶酚胺和心房钠素（ANP）水平的影响。青蒿素是一种具有弱α阻断作用的β受体阻滞剂。静息时，arotinolol治疗降低了平均动脉压（MAP）、心脏指数（CI）和心率（HR）， SHR患者的总外周阻力指数和局部血流动力学没有变化。急性应激对SHR血流动力学的影响更为显著。应激时，arinoolol可降低SHR的MAP、CI和HR，降低心肌和骨骼肌流量以及内脏、肾脏、大脑和皮肤血管阻力。青蒿素在WKY中的作用要小得多。应激也增加了SHR血浆儿茶酚胺和ANP水平。在静息状态和应激状态下的SHR中，青蒿素能提高这些激素。因此，青蒿素治疗对SHR的静息和应激血流动力学具有更大的抑制作用，并伴有血浆儿茶酚胺和ANP水平的增加。
We investigated the effects of chronic treatment with arotinolol, a beta-blocker with weak alpha-blocking potency, on hemodynamics and plasma levels of catecholamines and atrial natriuretic peptide (ANP) at rest and during stress in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. At rest, arotinolol treatment decreased mean arterial pressure (MAP), cardiac index (CI) and heart rate (HR), with no changes in total peripheral resistance index or regional hemodynamics in SHR. Acute stress caused more remarkable hemodynamic changes in SHR. During stress, arotinolol decreased MAP, CI and HR, and reduced myocardial and skeletal muscle flow and splanchnic, renal, cerebral and cutaneous vascular resistance in SHR. Arotinolol's effects were much less in WKY. Stress also increased the plasma catecholamine and ANP levels in SHR. Arotinolol raised these hormones in both strains at rest and in SHR during stress. Thus, arotinolol treatment exerted greater suppressive effects on the resting and stressed hemodynamics in SHR, with associated increases in the plasma catecholamine and ANP levels.