Frontal White Matter Volume Is Associated with Brain Enlargement and Higher Structural Connectivity in Anthropoid Primates
Frontal White Matter Volume Is Associated with Brain Enlargement and Higher Structural Connectivity in Anthropoid Primates
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DOI：
10.1371/journal.pone.0009123
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发表时间：
2010-02
期刊：
影响因子：
3.7
通讯作者：
J. Smaers;A. Schleicher;K. Zilles;L. Vinicius
中科院分区：
文献类型：
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作者：
J. Smaers;A. Schleicher;K. Zilles;L. Vinicius
先前的研究表明，额叶及其与其他大脑结构的“执行”连接在解释灵长类动物新皮层适应性方面至关重要。然而，尚未获得额叶结缔组织（白色物质）体积测量的代表性样本。在这项研究中，我们提出了新的体积测量白色和灰质的额叶和非额叶新皮质叶从18个物种。我们在现有的新皮层、额叶和白色与灰质超尺度理论的背景下分析这些数据。结果表明，新皮层白色对灰质的“普适标度定律”分别适用于额叶和非额叶，新皮层和额叶对大脑其余部分的超标度主要是由于额叶白色物质;而这一变化，（但非额叶）白色物质体积与大脑其余部分和基底神经节的变化相关，一组与“执行控制”功能相关的皮层下核团。结果表明，额叶白色物质在解释新皮层和额叶超尺度，大脑大小的变化和更高的神经结构连接在Escherids的核心作用。
Previous research has indicated the importance of the frontal lobe and its ‘executive’ connections to other brain structures as crucial in explaining primate neocortical adaptations. However, a representative sample of volumetric measurements of frontal connective tissue (white matter) has not been available. In this study, we present new volumetric measurements of white and grey matter in the frontal and non-frontal neocortical lobes from 18 anthropoid species. We analyze this data in the context of existing theories of neocortex, frontal lobe and white versus grey matter hyperscaling. Results indicate that the ‘universal scaling law’ of neocortical white to grey matter applies separately for frontal and non-frontal lobes; that hyperscaling of both neocortex and frontal lobe to rest of brain is mainly due to frontal white matter; and that changes in frontal (but not non-frontal) white matter volume are associated with changes in rest of brain and basal ganglia, a group of subcortical nuclei functionally linked to ‘executive control’. Results suggest a central role for frontal white matter in explaining neocortex and frontal lobe hyperscaling, brain size variation and higher neural structural connectivity in anthropoids.