Lifestyle-related risk factors for stomach cancer in northeast Thailand.
Lifestyle-related risk factors for stomach cancer in northeast Thailand.
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发表时间：
2008
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通讯作者：
K. Suwanrungruang;S. Sriamporn;S. Wiangnon;Dhanes Rangsrikajee;A. Sookprasert;Nakorn Thipsuntornsak;P. Sa
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作者：
K. Suwanrungruang;S. Sriamporn;S. Wiangnon;Dhanes Rangsrikajee;A. Sookprasert;Nakorn Thipsuntornsak;P. Sa
胃癌在泰国并不常见，但泰国人口的生活方式正在改变，变得更加西方化，因此需要规划胃癌控制方案的信息。这种肿瘤的发病率最高的地区是东亚，从日本Yamagata的95.5/105（男性）和40.1/105（女性）的年龄标准化发病率到泰国东北部孔敬的4.1/105（男性）和2.1/105（女性）。在泰国，1993年和1996年的估计年龄标准化发病率分别为男性4.9/10万和4.1/10万，女性3.0/10万和2.6/10万。泰国人胃癌的危险因素尚不清楚，但可能包括蔬菜和水果摄入量低，饮酒，吸烟和盐摄入量高。目的探讨饮食因素、吸烟和饮酒对泰国人群胃癌风险的影响。方法2002-2006年在泰国孔敬进行病例对照研究，研究这些因素在胃癌中的作用。胃癌组101例，对照组202例（病例：对照= 1：2）。3岁）和地区从孔敬省的Srinagarind医院和孔敬地区医院招募。所有病例均经病理证实。对照组有各种疾病，主要是眼疾。采用结构式问卷调查方法收集患者的饮食习惯、饮酒和吸烟情况，并采集血样进行进一步研究。结果病例组与对照组的一般特征分布、年龄和性别分布相似。在最终分析中，发现风险较高但无统计学意义的因素是长期吸烟（OR=1.9，95%CI：0.85-4.50），长期饮酒（OR=1.2，95%CI：0.51-2.60）和蔬菜和水果摄入量低（OR=1.2，95%CI：0.74-1.96）。高植物油摄入量（OR=4.5，95%CI：1.00.猪肉油（OR=1.4，95%CI：0.63-3.01）和jeawprik（主要冷冰冰的和plara肉汤）（OR=1.2，95%CI：0.76 - 2.01）也有类似的趋势。结论我们的研究证实了高摄入量的水果和蔬菜对胃癌发展的保护作用，并表明高摄入量的酱汁增加了亚洲其他国家的胃癌风险。
BACKGROUND Stomach cancer is not common in Thailand but the life styles of the Thai population are changing to become more Western so that information for planning control programme of stomach cancer is necessary. The highest incidence rates of this neoplasm are found in Eastern Asia, ranging from age-standardized rates of 95.5/105 (men) and 40.1/105 (women) in Yamagata, Japan to 4.1/105 (men) and 2.1/105 (women) in Khon Kaen, Northeast of Thailand. In Thailand, the estimated age-standardized incidence rates in 1993, 1996 were 4.9/105, 4.1/105 in men and 3.0/105 , 2.6/105 in women. Risk factors for stomach cancer in Thai population are unclear, but possibly include low intake of vegetables and fruits, alcohol drinking, tobacco smoking and high intake of salt. OBJECTIVE To investigate various aspects of dietary factors, smoking, and alcohol drinking in determining risk of stomach cancer in Thai population. METHODS A case-control study was conducted in Khon Kaen, Thailand during 2002-2006, to study the role of these factors in stomach cancer. 101 stomach cancer cases and 202 matched controls (case : control = 1:2) by sex, age (? 3 years) and region were recruited from Srinagarind Hospital and Khon Kaen Regional Hospital, in Khon Kaen Province. All of cases were histologically confirmed. Controls had a variety of diseases, the main ones being disease of the eye. Information on dietary habits, alcohol drinking and smoking were collected by a structured questionnaire, blood samples were collected for further study. RESULTS The distribution of the general characteristics by case-control status, the distribution of age and sex were similar in cases and controls. In the final analysis, the factors that found to be higher risk but not statistically significant were long-term filter cigarette smoking (OR=1.9, 95%CI: 0.85-4.50), long-term alcohol consumption (OR=1.2, 95%CI: 0.51-2.60) and low intake of vegetables and fruits (OR=1.2, 95%CI: 0.74-1.96). A high intake of vegetable oil (OR=4.5, 95%CI: 1.00.-20.17) was found to be associated with increased risk, and similar tendencies were noted for pork oil (OR=1.4, 95%CI: 0.63-3.01) and jeaw prik (mainly chilly with plara broth) (OR=1.2, 95%CI: 0 .76- 2.01). CONCLUSION Our study confirmed protective effects of a high intake of fruits and vegetables against stomach cancer development and showed a high intake of sauces to increase risk of stomach cancer as in other countries in Asia.