Value of wash-in and wash-out time in the diagnosis between hepatocellular carcinoma and other hepatic nodules with similar vascular pattern on contrast-enhanced ultrasound
Value of wash-in and wash-out time in the diagnosis between hepatocellular carcinoma and other hepatic nodules with similar vascular pattern on contrast-enhanced ultrasound
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DOI：
10.1111/jgh.12394
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发表时间：
2014-03-01
影响因子：
4.1
通讯作者：
Mao, Feng
中科院分区：
文献类型：
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作者：
Kong, Wen-Tao;Wang, Wen-Ping;Mao, Feng
背景和目的本研究旨在证明在超声造影（CEUS）上，洗入和洗出时间是否可以作为肝细胞癌（HCC）与其他具有类似HCC血管模式的肝结节的鉴别诊断的可靠标准。214例CEUS显示快速增强和快速洗脱的肝结节患者纳入本研究。在进行CEUS之前，所有结节均进行了灰阶超声和彩色多普勒技术检查。超声造影采用SonoVue低机械指数技术。结果214个肝细胞癌结节中，209个为恶性，209个为非恶性，209个为良性，209个为恶性，（164例HCC，31例转移瘤，10例肝内胆管癌（ICC），3例肝细胞-胆管癌联合癌，1例上皮样血管内皮瘤），5例良性（2例炎性假瘤、1例局灶性结节性增生结节、1例血管瘤和1例增生结节）。转移瘤和ICC的洗脱速度快于HCC（P
Background and AimThe study aims to demonstrate whether the wash-in and wash-out time can be reliable as a criterion in the differential diagnosis between hepatocellular carcinoma (HCC) and other hepatic nodules with vascular pattern similar to HCC on contrast-enhanced ultrasound (CEUS).MethodsFrom February 2012 to February 2013, 214 patients with hepatic nodules displayed rapid hyperenhancement and quick wash-out on CEUS were included in this study. Before performing CEUS, all nodules were examined by grayscale ultrasonography and color Doppler techniques. CEUS was performed with SonoVue and low mechanical index technique. The initial time to enhancement, time to peak, time of the nodule being hypoenhanced were comparatively studied between HCCs and other hepatic nodules.ResultsOf all the 214 nodules, 209 were malignant (164 HCCs, 31 metastases, 10 intrahepatic cholangiocarcinomas (ICCs), 3 combined hepatocellular-cholangiocarcinomas, 1 epithelioid hemangioendothelioma), and five were benign (two inflammatory pseudotumors, one focal nodular hyperplasia nodule, one hemangioma, and one hyperplastic nodule). Metastases and ICCs showed more rapid wash-out than HCCs (P