Cord blood leptin reflects fetal fat mass
Cord blood leptin reflects fetal fat mass
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DOI：
10.1016/s1071-5576(98)00028-8
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发表时间：
1998-11-01
期刊：
影响因子：
--
通讯作者：
Kiess, W
中科院分区：
文献类型：
--
作者：
Clapp, JF;Kiess, W
目的：探讨瘦素水平与出生时脂肪质量的关系，以检验胎儿循环中的瘦素水平主要是胎儿脂肪质量的指标的假设。方法：测定42名妇女的后代的脐带血中的瘦素浓度。分娩后获得修剪、引流的胎盘重量和新生儿形态测量学。母体体重范围（46.7-93.2公斤），体重增加（3.2-22.6 kg），体脂百分比（10-34%），胎盘重量（290-688 g）、出生体重（2.63-4.32 kg）、新生儿脂肪质量（179-782 g）和脐带血瘦素（1.7-26.7 ng/mL）的范围较广。唯一能解释脐带血瘦素水平显著变化的形态计量学变量是新生儿脂肪量（r（2）= 0.41），而这种关系并没有通过额外的胎儿和胎盘形态计量学变量的最佳子集回归得到显著改善（r（2）= 0.46）。这些数据支持了安的假设，即在胎儿中，就像在儿童和成人中一样，脂肪量是循环中瘦素水平的主要决定因素。版权所有（C）1998由妇科调查协会。
OBJECTIVE: To explore the relationship between leptin levels and fat mass at the time of birth to test the hypothesis that the level of leptin in the fetal circulation is primarily an index of fetal fat mass.METHODS: Leptin concentration was measured in cord blood obtained from the offspring of 42 women. Trimmed, drained placental weight and neonatal morphometrics were obtained after delivery.RESULTS: The ranges in maternal weight (46.7-93.2 kg), weight gain (3.2-22.6 kg), percent body fat (10-34%), placental weight (290-688 g), birth weight (2.63-4.32 kg), neonatal fat mass (179-782 g), and cord blood leptin (1.7-26.7 ng/mL) were wide. The only morphometric variable that explained a significant portion of the variation in cord blood leptin levels lear neonatal fat mass (r(2) = 0.41), and this relationship was not significantly improved by best subset regression of additional fetal and placental morphometric variables (r(2) = 0.46).CONCLUSION: These data support the hypothesis ann suggest that in the fetus, as in the child and the adult, fat mass is the major determinant of circulating leptin levels. Copyright (C) 1998 by the Society for Gynecologic Investigation.