DIAGNOSTIC SENSITIVITY BIAS - AN EPIDEMIOLOGIC EXPLANATION FOR AN APPARENT BRAIN-TUMOR EXCESS
DIAGNOSTIC SENSITIVITY BIAS - AN EPIDEMIOLOGIC EXPLANATION FOR AN APPARENT BRAIN-TUMOR EXCESS
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DOI：
10.1097/00043764-198110000-00012
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发表时间：
1981-01-01
影响因子：
3.2
通讯作者：
EARLE, K
中科院分区：
文献类型：
--
作者：
GREENWALD, P;FRIEDLANDER, BR;EARLE, K
初步数据显示，伊士曼柯达公司（罗切斯特）在脑肿瘤患者的死亡证明上的代表性过高，与一般人群相比，老年工人的风险更高，这导致了一项病例对照流行病学研究。研究人员将56名患有脑瘤的员工与其他柯达员工的化学物质接触史进行了比较。暴露在各种化学物质中没有发现差异。患有脑瘤的员工与纽约州北部的其他脑瘤患者进行了比较；两组在组织学上无差异。柯达员工的诊断更频繁地得到组织学检查和更彻底的诊断研究的证实。最初诊断出的肿瘤明显过多，可能是由于对柯达员工进行更全面的医疗评估而导致的诊断敏感性偏差。
Preliminary data showing over-representation of the Eastman Kodak Company (Rochester) on death certificates of brain tumor patients, and higher risk for older workers when compared to the general population, led to a case control epidemiologic study. Chemical exposure histories of 56 workers with brain tumors were compared with those of other Kodak employees. No differences were found in exposure to a variety of chemicals. Employees with brain tumors were compared to other upstate New York brain tumor patients; there was no difference in histology. The Kodak employees had diagnoses more frequently confirmed by histologic examination and more thorough diagnostic studies. The apparent initial excess of diagnosed tumors may have resulted from a diagnostic sensitivity bias arising from more complete medical evaluation of Kodak employees.