OVALOCYTOSIS PROTECTS AGAINST SEVERE MALARIA PARASITEMIA IN THE MALAYAN ABORIGINES
OVALOCYTOSIS PROTECTS AGAINST SEVERE MALARIA PARASITEMIA IN THE MALAYAN ABORIGINES
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DOI：
10.4269/ajtmh.1992.47.271
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发表时间：
1992-09-01
影响因子：
3.3
通讯作者：
MAK, JW
中科院分区：
文献类型：
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作者：
FOO, LC;REKHRAJ, V;MAK, JW
疟疾寄生虫率和密度进行了比较，在79个卵圆细胞，normocytic对匹配的年龄，性别，居住地接近对方，并使用蚊帐时，他们在马来西亚半岛中部的丛林定居点睡觉。疟疾感染是从厚和薄的吉姆萨染色血膜每月收集的为期六个月。红细胞正常者血膜阳性率低于卵红细胞正常者（P < 0.05）。每100人月的疟疾感染风险在卵细胞组为9.7，而在正常细胞组为15.19。在任何时候都有寄生虫血症的个体中，恶性疟原虫、间日疟原虫和三日疟原虫的重度感染（大于或等于10，000个寄生虫/mm 3血液）仅发生在红细胞正常的受试者中，约占该组疟疾阳性个体的12.5%。在早期的一项对629名定居者的调查中，发现卵圆细胞增多症的患病率随年龄的增长而显著增加。上述实地观察支持这样的观点，即卵细胞型个体在面对疟疾时可能具有生存优势。在今后评价卵细胞增多症流行地区的疟疾防治措施时，应考虑卵细胞因素。
The malaria parasite rates and densities were compared in 79 ovalocytic-normocytic pairs of Malayan Aborigines matched for age, sex, proximity of residence to each other, and use of bed nets when sleeping in their jungle settlement in central Peninsular Malaysia. Malaria infection was determined from thick and thin Giemsa-stained blood films collected monthly for a period of six months. Blood films from ovalocytic individuals were found to be positive for malaria less often than in persons with normal red blood cells (P < 0.05). Malaria infections per 100 person-months at risk were 9.7 in the ovalocytic group compared with 15.19 in the normocytic group. Among individuals parasitemic at anytime, heavy infections (greater-than-or-equal-to 10,000 parasites/mm3 of blood) with Plasmodium falciparum, P. vivax, and P. malariae were encountered only in normocytic subjects, which comprised approximately 12.5% of the malaria-positive individuals in this group. In an earlier survey of 629 settlers that identified subjects for the above study, the prevalence of ovalocytosis was found to increase significantly with age. The above field observations support the view that ovalocytic individuals might have a survival advantage in the face of malaria. Consideration of the ovalocytic factor is indicated in future evaluations of malaria control measures in areas where ovalocytosis is prevalent.