Relations of cigarette smoking and dietary antioxidants with placental calcification.
Relations of cigarette smoking and dietary antioxidants with placental calcification.
复制标题
吸烟和膳食抗氧化剂与胎盘钙化的关系。
DOI：
10.1093/oxfordjournals.aje.a009424
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发表时间：
1998
影响因子：
5
通讯作者：
Goldenberg,RL
中科院分区：
文献类型：
--
作者：
Klesges,LM;Murray,DM;Brown,JE;Cliver,SP;Goldenberg,RL
孕妇吸烟与胎盘加速成熟（以组织钙化来衡量）之间的关系已有报道。作者试图解决膳食抗氧化剂，维生素C，α-生育酚和β-胡萝卜素的摄入量是否与孕妇表面和绒毛的胎盘钙化有关，在一组吸烟者和非吸烟者中，有分娩小于胎龄儿的风险。对1985年12月至1988年10月在亚拉巴马伯明翰伯明翰医院的亚拉巴马大学分娩单胎的黑人和白色妇女进行了一项前瞻性研究，对胎盘进行了大体和组织学检查，分别确定了胎盘表面（n= 1,213）和绒毛部位（n= 730）的钙化。控制种族和胎龄，表面和绒毛钙化的可能性随着吸烟水平的增加而增加。在控制吸烟和妊娠后，绒毛钙化的显著减少与α-生育酚的摄入有关，而β-胡萝卜素和维生素C的摄入与黑人而非白色妇女钙化的显著减少有关。未发现表面钙化与抗氧化剂摄入有关。作者的发现证实了吸烟和胎盘钙化之间的病理关系，并提示饮食中的抗氧化剂可以减少绒毛钙化。美国流行病学杂志1998;147：127-35。
Associations between matermal cigarette smoking and accelerated placental maturation measured as tissue calcification have been reported. The authors sought to address whether intakes of the dietary antioxidants, vitamin C, alpha-tocopherol, and beta-carotene, were related to placental calcification of the maternal surface and villi in a cohort of smokers and nonsmokers at risk for delivering small-for-gestational age infants. Gross and histologic examination of placentas were used to determine calcification at the surface (n= 1,213) and villus sites (n= 730), respectively, in a prospective study of black and white women who delivered singleton births between December 1985 and October 1988 at the University of Alabama at Birmingham Hospital in Birmingham, Alabama. Controlling for race and gestational age, likelihood of surface and villus calcification increased as smoking levels increased. Significant reductions in villus calcification were related to alpha-tocopherol intake after controlling for smoking and gestation while intakes of beta-carotene and vitamin C were related to significant reductions in calcification for black but not white women. Surface calcification was not found to be related to antioxidant intake. The authors' findings confirm a pathologic relation between smoking and placental calcification and suggest that dietary antioxidants may reduce villus calcification.Am J Epidemiol1998;147: 127–35.