Blood capillary enlargement during the development of thyroid hyperplasia in the rat.
Blood capillary enlargement during the development of thyroid hyperplasia in the rat.
复制标题
大鼠甲状腺增生发展过程中毛细血管扩张。
作者：
S. H. Wollman;J. Herveg;J. Zeligs;L. Ericson
为了研究增生性甲状腺的毛细血管生长，大鼠在低碘饮食中饲喂0.25%硫脲嘧啶，间隔时间长达100天。甲状腺经血管灌注固定，Epon包埋。整叶从一根到另一根切片，每0.3 mm切片制作载玻片。毛细血管在第3天明显增大，此后逐渐增大。到第3天，许多相邻的毛细血管细胞靠近，从这个时候开始，毛细血管壁以部分间隔的形式融合在毛细血管腔中。融合持续到20天，此时卵泡几乎完全被连续的内皮片包围，未融合的毛细血管壁被结缔组织分开。外周滤泡周围的血管形态变化与内滤泡相似，只是在某些地方，毛细血管逐渐从上皮和甲状腺包膜之间的间隙中排除。血管扩张仅限于甲状腺血管。甲状旁腺虽靠近甲状腺，但毛细血管未见明显扩张。
To study blood capillary growth in the hyperplastic thyroid gland, rats were fed 0.25% thiouracil in a low iodine diet for time intervals up to 100 days. Thyroids were fixed by vascular perfusion and embeded in Epon. Whole lobes were sectioned from pole to pole and slides were prepared of sections every 0.3 mm. Capillaries were clearly enlarged by 3 days and they enlarged progressively thereafter. By 3 days, the cells of many neighboring capillaries came into close apposition and from this time on, there was evidence of fusion of capillary walls in the form of partial septa in the capillary lumens. Fusion continued until 20 days, when follicles were almost completely surrounded by a continuous endothelial sheet and unfused capillary walls were separated by connective tissue. The vascular pattern around peripheral follicles changed in a way similar to interior follicles, except that in places, capillaries were gradually excluded from the space between epithelium and thyroid capsule. Vascular enlargement was restricted to the thyroid blood vessels. There was no obvious enlargement of the blood capillaries of the parathyroid despite its close proximity to the thyroid.