Over-expression of COX-2 induces human ovarian cancer cells (CAOV-3) viability, migration and proliferation in association with PI3-k/Akt activation
Over-expression of COX-2 induces human ovarian cancer cells (CAOV-3) viability, migration and proliferation in association with PI3-k/Akt activation
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DOI：
10.1080/07357900801941860
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发表时间：
2008-01-01
影响因子：
2.4
通讯作者：
Cai, Youqun
中科院分区：
文献类型：
--
作者：
Gu, Pingqing;Su, Yajuan;Cai, Youqun
考克斯-2参与多种病理过程。考克斯-2对人卵巢癌细胞株CAOV-3的作用及相关信号通路尚未得到证实。本研究探讨了考克斯-2对CAOV-3细胞存活、迁移及增殖的影响，并进一步探讨了PI 3-k/Akt在其中的作用。结果表明，考克斯-2能促进细胞的存活、迁移和CAOV-3的表达。LY 294002可降低考克斯-2诱导的细胞活力、迁移和增殖。提示考克斯-2通过PI 3-k/Akt信号通路诱导CAOV-3细胞的存活和迁移，并促进其增殖。
COX-2 is involved in several pathological processes. The action of COX-2 on human ovarian cancer cell line (CAOV-3) and relative signal pathway has not been demonstrated. We explored the effects of COX-2 on the CAOV-3 viability and migration, moreover the proliferation of CAOV-3, and then ascertained the roles of PI3-k/Akt in these processes. The results showed that COX-2 increased the cells viability, migration and augment the number of CAOV-3. LY294002 could reduce COX-2 induce cells viability, migration and proliferation. These data indicate that COX-2 induce cells viability and migration, moreover promote the proliferation of CAOV-3 via PI3-k/Akt signal pathway.