The association of HLA-DR3 with specific IgE to inhaled acid anhydrides.
The association of HLA-DR3 with specific IgE to inhaled acid anhydrides.
复制标题
HLA-DR3 与吸入酸酐的特异性 IgE 的关联。
DOI：
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发表时间：
1995
影响因子：
24.7
通讯作者：
A J Taylor
中科院分区：
文献类型：
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作者：
R. P. Young;R D Barker;K D Pile;W O Cookson;A J Taylor
我们对酸酐工人中的 HLA 等位基因频率与酸酐-人血清白蛋白 (AA-HSA) 结合物特异性 IgE 抗体之间的关联进行了案例参考研究。将 30 例放射性过敏吸附剂测试得分与 AA-HSA 缀合物 > 2 的病例与从与病例相同的工厂地点选择的 30 例无特异性 IgE 的参考对象进行比较，并匹配年龄、性别、暴露时间、特应性状态和吸烟习惯。我们发现，与参考对象相比，具有针对酸酐的特异性 IgE 的病例中 HLA-DR3 显着过量（50% 与 14%，Fisher 统计 = 8.4；比值比 = 6，p = 0.05 校正）。 HLA-DR3 过量与 IgE 与偏苯三酸酐尤其相关，11 名患有 IgE 的工人中有 8 名存在 HLA-DR3，14 名没有 IgE 的工人中有 2 名存在 HLA-DR3（Fisher 统计 = 8.5，比值比 = 16，p = 0.004）。邻苯二甲酸酐工人中 HLA-DR3 的比例在具有 IgE 的工人（12 人中的 2 人）与其参考对象（14 人中的 2 人）中没有不同。这些发现表明 MHC II 蛋白是 IgE 对吸入半抗原反应特异性的重要决定因素。
We have undertaken a case referent study of the association between HLA allele frequency and specific IgE antibody to acid anhydride-human serum albumin (AA-HSA) conjugates among acid anhydride workers. Thirty cases with radio-allergosorbent test score versus AA-HSA conjugates > 2 were compared with 30 referents without specific IgE selected from the same factory sites as the cases and matched for age, sex, duration of exposure, atopic status, and smoking habit. We found a significant excess of HLA-DR3 in the cases with specific IgE to acid anhydrides when compared with the referents (50% versus 14%, Fisher's statistic = 8.4; odds ratio = 6, p = 0.05 corrected). The excess of HLA-DR3 was particularly associated with IgE versus trimellitic anhydride, with HLA-DR3 present in eight of 11 workers with and in two of 14 referents without IgE (Fisher's statistic = 8.5, odds ratio = 16, p = 0.004). The proportion of HLA-DR3 among the phthalic anhydride workers was not different in those with IgE (two of 12) from their referents (two of 14). These findings suggest MHC II proteins are an important determinant of the specificity of the IgE response to an inhaled hapten.