Significant correlation between openness personality in normal subjects and brain myelin mapping with T1/T2-weighted MR imaging.
Significant correlation between openness personality in normal subjects and brain myelin mapping with T1/T2-weighted MR imaging.
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DOI：
10.1016/j.heliyon.2017.e00411
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发表时间：
2017-09
期刊：
影响因子：
4
通讯作者：
Kishimoto T
中科院分区：
文献类型：
--
作者：
Yasuno F;Kudo T;Yamamoto A;Matsuoka K;Takahashi M;Iida H;Ihara M;Nagatsuka K;Kishimoto T
本研究的目的是探讨髓鞘形成和开放性的经验在年轻认知正常志愿者的心理特征之间的关系，使用区域T1加权（T1 w）/T2 w的比率在磁共振成像（MRI）。假设轴突髓鞘形成与开放性有关，从而将特质创造力和精神疾病联系起来。我们招募了37名健康受试者，并使用NEO五因素量表评估人格因素。计算局部T1 w/T2 w MRI值作为髓鞘形成状态的替代指标以及T1 w/T2 w值与各种个性因素（例如，开放性特征）的计算与基于体素的分析，使用统计参数映射。开放性与内侧额叶皮层、前扣带回皮层、后扣带回皮层和后扣带回/邻近壳核的T1 w/T2 w值呈显著负相关。即使在调整了年龄、性别和教育程度作为协变量后，这些关系仍然显着。其他人格因素与区域容量之间无显著相关。开放性的个体差异可能与皮层内髓鞘形成的变化有关，特别是在大脑的想象网络中，包括默认模式网络的中线核心“枢纽”（前扣带回/内侧额叶皮层和后扣带回皮层）和与动机状态相关的区域（后扣带回和邻近的壳核）。与髓鞘形成减少相关的信号干扰可能促进灵活的想象力和开放性的特征。我们的发现有助于理解髓鞘形成和开放性之间的关系，作为创造力和精神疾病之间的联系。
The objective of this study was to examine the relationship between the myelination and the psychological trait of openness to experience in young cognitively normal volunteers using regional T1-weighted (T1w)/T2w ratios on magnetic resonance imaging (MRI). It was hypothesized that axonal myelination would be related to openness, thus linking trait creativity and mental illness. We recruited 37 healthy subjects and administered the NEO Five-Factor Inventory to assess personality factors. Regional T1w/T2w MRI values were computed as surrogate indicators of myelination status and correlations between T1w/T2w values and various personality factors (e.g., trait of openness) were calculated with a voxel-based analysis using statistical parametric mapping. Significant negative correlations were identified between the trait of openness and T1w/T2w values in the medial frontal cortex, anterior cingulate cortex, posterior cingulate cortex, and posterior insula/adjacent putamen. These relationships remained significant even after adjusting for age, sex, and education as covariates. There were no significant correlations between other personality factors and regional volumes. Individual differences in openness may be associated with variations in intra-cortical myelination, specifically in the imaginative network of the brain including the midline core ‘hubs’ of the default mode network (anterior cingulate/medial frontal cortex and posterior cingulate cortex) and regions related to motivational state (posterior insula and adjacent putamen). Signal interference related to decreased myelination may facilitate flexible imagination and the trait of openness. Our findings assist in understanding the relationship between myelination and openness, as a link between creativity and mental illness.