Tumor acidity as evolutionary spite.
Tumor acidity as evolutionary spite.
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DOI：
10.3390/cancers3010408
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发表时间：
2011-01-20
期刊：
影响因子：
5.2
通讯作者：
Shayoub ME
中科院分区：
文献类型：
--
作者：
Alfarouk KO;Muddathir AK;Shayoub ME
大多数癌细胞将其代谢途径从反映巴斯德效应的代谢转变为反映沃伯格效应的代谢。这种转变在肿瘤周围创造了一个酸性微环境，并成为积极致癌反馈回路的驱动力。作为肿瘤酸性的结果，肿瘤微环境鼓励选择某些细胞表型，这些细胞表型能够在这种腐蚀性环境中存活，而损害其他细胞类型。这种选择可以用一个过程来描述，这个过程可以模仿尽管：肿瘤细胞通过制造酸性环境来降低自己的适应性，但这在更大程度上降低了竞争对手的适应性。此外，环境是进一步推动这种怨恨过程的一个重要方面。因此，减少选择性环境很可能会干扰怨恨过程。这种干扰最近已被用于癌症治疗。
Most cancer cells shift their metabolic pathway from a metabolism reflecting the Pasteur-effect into one reflecting the Warburg-effect. This shift creates an acidic microenvironment around the tumor and becomes the driving force for a positive carcinogenesis feedback loop. As a consequence of tumor acidity, the tumor microenvironment encourages a selection of certain cell phenotypes that are able to survive in this caustic environment to the detriment of other cell types. This selection can be described by a process which can be modeled upon spite: the tumor cells reduce their own fitness by making an acidic environment, but this reduces the fitness of their competitors to an even greater extent. Moreover, the environment is an important dimension that further drives this spite process. Thus, diminishing the selective environment most probably interferes with the spite process. Such interference has been recently utilized in cancer treatment.