Ten-Year Outcome of Islet Alone or Islet After Kidney Transplantation in Type 1 Diabetes: A Prospective Parallel-Arm Cohort Study
Ten-Year Outcome of Islet Alone or Islet After Kidney Transplantation in Type 1 Diabetes: A Prospective Parallel-Arm Cohort Study
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DOI：
10.2337/dc19-0401
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发表时间：
2019-11-01
期刊：
影响因子：
16.2
通讯作者：
Pattou, Francois
中科院分区：
文献类型：
--
作者：
Vantyghem, Marie-Christine;Chetboun, Mikael;Pattou, Francois
目的：同种异体胰岛移植的长期效果尚不清楚。本研究的目的是评价1型糖尿病伴低血糖意识不清和/或移植肾功能正常患者胰岛移植的10年预后。研究设计和方法：我们在这项前瞻性平行臂队列研究中纳入了28例1型糖尿病患者，他们接受了单独胰岛移植（ITA）或肾移植后胰岛移植（IAK）。胰岛移植包括在（中位数[四分位数间距]）68天内（43-92）进行两次或三次同种异体胰岛门静脉内输注。用白细胞介素-2受体抗体诱导免疫抑制，并用西罗莫司和他克莫司维持。主要结局是A1 C的胰岛素依赖性
OBJECTIVE The long-term outcome of allogenic islet transplantation is unknown. The aim of this study was to evaluate the 10-year outcome of islet transplantation in patients with type 1 diabetes and hypoglycemia unawareness and/or a functioning kidney graft. RESEARCH DESIGN AND METHODS We enrolled in this prospective parallel-arm cohort study 28 subjects with type 1 diabetes who received islet transplantation either alone (ITA) or after a kidney graft (IAK). Islet transplantation consisted of two or three intraportal infusions of allogenic islets administered within (median [interquartile range]) 68 days (43-92). Immunosuppression was induced with interleukin-2 receptor antibodies and maintained with sirolimus and tacrolimus. The primary outcome was insulin independence with A1C